Any feedback?
Literature summary for 2.8.2.11 extracted from
- Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides (2009), Biochem. Biophys. Res. Commun., 390, 1382-1388.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the mechanism, indicating the crosstalk between kidney injury and specific liver functions, may prove useful to understand the situation where human hemodialysis patients have low levels of serum sulfatides | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | sulfatide synthesis from galactosylceramides | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | sulfatide synthesis from galactosylceramides | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cerebroside sulfotransferase | - |
Mus musculus |
| CST | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | altered expression via protein-overload treatment, protein and gene expression of CST is significantly decreased in the liver in a time-dependent manner | down |
| Mus musculus | altered expression via protein-overload treatment, renal expression of CST is markedly increased | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | CST is involved in sulfatide biosynthesis | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
