Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.2.1 extracted from

  • Yamamoto, A.; Kurogi, K.; Schiefer, I.T.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
    Human cytosolic sulfotransferase SULT1A3 mediates the sulfation of dextrorphan (2016), Biol. Pharm. Bull., 39, 1432-1436 .
    View publication on PubMed
Search for more literature for 2.8.2.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P0DMM9 isoform SULT1A3
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00194
-
 substrate dextrorphan, pH 7.0, 37°C Homo sapiens
0.00293
-
 substrate 4-nitrophenol, pH 7.0, 37°C Homo sapiens
0.0781
-
 substrate dopamine, pH 7.0, 37°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + dextrorphan i.e. active metabolite of the antitussive dextromethorphan Homo sapiens adenosine 3',5'-bisphosphate + dextrorphan sulfate
-
 ?
3'-phosphoadenylyl sulfate + dopamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
SULT1A3
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism of all thirteen known human SULTs, isoform SULT1A3 displays the strongest dextrorphan-sulfating activity Homo sapiens