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Literature summary for 2.8.2.1 extracted from

  • Bairam, A.F.; Rasool, M.I.; Alherz, F.A.; Abunnaja, M.S.; El Daibani, A.A.; Kurogi, K.; Liu, M.C.
    Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3 (2018), Arch. Biochem. Biophys., 648, 44-52 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
K234N missense SNP for the SULT1A3 gene Homo sapiens
N235T missense SNP for the SULT1A3 gene Homo sapiens
P101H missense SNP for the SULT1A3 gene Homo sapiens
P101L missense SNP for the SULT1A3 gene Homo sapiens
P10L missense SNP for the SULT1A3 gene Homo sapiens
P19L missense SNP for the SULT1A3 gene Homo sapiens
R144C missense SNP for the SULT1A3 gene Homo sapiens
R9C missense SNP for the SULT1A3 gene Homo sapiens
S290T missense SNP for the SULT1A3 gene Homo sapiens
S8P missense SNP for the SULT1A3 gene Homo sapiens
T7P missense SNP for the SULT1A3 gene Homo sapiens
V15M missense SNP for the SULT1A3 gene Homo sapiens
V18F missense SNP for the SULT1A3 gene Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 tapentadol mutant P101H, pH 7.4, 37°C Homo sapiens
0.11
-
 tapentadol mutant R144C, pH 7.4, 37°C Homo sapiens
0.15
-
 tapentadol wild-type, pH 7.4, 37°C Homo sapiens
0.19
-
 tapentadol mutant T7P, pH 7.4, 37°C Homo sapiens
0.21
-
 tapentadol mutant S290T, pH 7.4, 37°C Homo sapiens
0.24
-
 tapentadol mutant P101L, pH 7.4, 37°C Homo sapiens
0.27
-
 O-desmethyl tramadol mutant P101H, pH 7.4, 37°C Homo sapiens
0.32
-
 tapentadol mutant P10L, pH 7.4, 37°C Homo sapiens
0.32
-
 tapentadol mutant V18F, pH 7.4, 37°C Homo sapiens
0.34
-
 tapentadol mutant R9C, pH 7.4, 37°C Homo sapiens
0.35
-
 O-desmethyl tramadol mutant R144C, pH 7.4, 37°C Homo sapiens
0.38
-
 tapentadol mutant V15M, pH 7.4, 37°C Homo sapiens
0.43
-
 acetaminophen mutant P101H, pH 7.4, 37°C Homo sapiens
0.46
-
 O-desmethyl tramadol wild-type, pH 7.4, 37°C Homo sapiens
0.48
-
 O-desmethyl tramadol mutant S290T, pH 7.4, 37°C Homo sapiens
0.48
-
 tapentadol mutant S8P, pH 7.4, 37°C Homo sapiens
0.5
-
 O-desmethyl tramadol mutant T7P, pH 7.4, 37°C Homo sapiens
0.5
-
 O-desmethyl tramadol mutant V18F, pH 7.4, 37°C Homo sapiens
0.51
-
 O-desmethyl tramadol mutant R9C, pH 7.4, 37°C Homo sapiens
0.53
-
 O-desmethyl tramadol mutant P10L, pH 7.4, 37°C Homo sapiens
0.54
-
 O-desmethyl tramadol mutant P101L, pH 7.4, 37°C Homo sapiens
0.55
-
 tapentadol mutant K234N, pH 7.4, 37°C Homo sapiens
0.57
-
 O-desmethyl tramadol mutant V15M, pH 7.4, 37°C Homo sapiens
0.58
-
 O-desmethyl tramadol mutant K234N, pH 7.4, 37°C Homo sapiens
0.63
-
 acetaminophen wild-type, pH 7.4, 37°C Homo sapiens
0.63
-
 acetaminophen mutant K234N, pH 7.4, 37°C Homo sapiens
0.66
-
 O-desmethyl tramadol mutant S8P, pH 7.4, 37°C Homo sapiens
0.67
-
 acetaminophen mutant S8P, pH 7.4, 37°C Homo sapiens
0.72
-
 acetaminophen mutant V15M, pH 7.4, 37°C Homo sapiens
0.73
-
 acetaminophen mutant T7P, pH 7.4, 37°C Homo sapiens
0.78
-
 acetaminophen mutant V18F, pH 7.4, 37°C Homo sapiens
0.8
-
 O-desmethyl tramadol mutant N235T, pH 7.4, 37°C Homo sapiens
0.84
-
 tapentadol mutant N235T, pH 7.4, 37°C Homo sapiens
0.97
-
 acetaminophen mutant P10L, pH 7.4, 37°C Homo sapiens
0.98
-
 acetaminophen mutant P101L, pH 7.4, 37°C Homo sapiens
1.05
-
 acetaminophen mutant S290T, pH 7.4, 37°C Homo sapiens
1.25
-
 acetaminophen mutant R9C, pH 7.4, 37°C Homo sapiens
1.97
-
 acetaminophen mutant R144C, pH 7.4, 37°C Homo sapiens
3.8
-
 morphine mutant P101H, pH 7.4, 37°C Homo sapiens
4.5
-
 acetaminophen mutant N235T, pH 7.4, 37°C Homo sapiens
4.6
-
 morphine wild-type, pH 7.4, 37°C Homo sapiens
5
-
 morphine mutant R9C, pH 7.4, 37°C Homo sapiens
5
-
 morphine mutant V15M, pH 7.4, 37°C Homo sapiens
5.7
-
 morphine mutant T7P, pH 7.4, 37°C Homo sapiens
5.7
-
 morphine mutant V18F, pH 7.4, 37°C Homo sapiens
5.9
-
 morphine mutant P10L, pH 7.4, 37°C Homo sapiens
6.2
-
 morphine mutant S290T, pH 7.4, 37°C Homo sapiens
6.4
-
 morphine mutant P101L, pH 7.4, 37°C Homo sapiens
7.2
-
 morphine mutant R144C, pH 7.4, 37°C Homo sapiens
7.8
-
 morphine mutant S8P, pH 7.4, 37°C Homo sapiens
8.3
-
 morphine mutant K234N, pH 7.4, 37°C Homo sapiens
10
-
 morphine mutant N235T, pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens P0DMM9 isoform SULT1A3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + acetaminophen
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + morphine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + O-desmethyl tramadol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + tapentadol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
SULT1A3
-
 Homo sapiens