Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | SULT1A1 and SULT1A3 are potently inhibited by natural products present in juices, apple, grape, grapefruit, green and black teas, and coffee | Homo sapiens | |
quercetin | found in many fruits, vegetables and wine, is a potent inhibitor of the sulfation of 4-nitrophenol, estradiol, and several drug substrates in human liver cytosol and with recombinantly expressed human SULT1A1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is active in conjugating the polychlorobiphenyl alcohols, e.g. 3'-OH-trichlorobiphenyl, 4'-OH-trichlorobiphenyl and 4'-OH-(chlorobiphenyl)112, SULT2A1 is active with 4-OH-(chlorobiphenyl)34 and 4'-OH-(chlorobiphenyl)68, but not with 4'-OH-nonachlorobiphenyl | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is active in conjugating the polychlorobiphenyl alcohols, e.g. 3'-OH-trichlorobiphenyl, 4'-OH-trichlorobiphenyl and 4'-OH-(chlorobiphenyl)112, SULT2A1 is active with 4-OH-(chlorobiphenyl)34 and 4'-OH-(chlorobiphenyl)68, but not with 4'-OH-nonachlorobiphenyl | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAPS-sulfotransferase | - |
Homo sapiens |
SULT | - |
Homo sapiens |
SULT1A1 | - |
Homo sapiens |
SULT1A3 | - |
Homo sapiens |
SULT1E1 | - |
Homo sapiens |
SULT2A1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.001 | - |
below, SULT1A1 | Homo sapiens | quercetin | |
0.001 | - |
SULT1E1 | Homo sapiens | quercetin | |
0.064 | - |
SULT2A1 | Homo sapiens | quercetin |
General Information | Comment | Organism |
---|---|---|
metabolism | sulfonation, catalyzed by PAPS-sulfotransferases, especially SULT2A1,is one major phase II pathways for polychlorobiphenylols conjugation and for elimination of the potentially toxic compounds, overview | Homo sapiens |