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Literature summary for 2.8.2.1 extracted from

  • Stakhiv, T.M.; Mesia-Vela, S.; Kauffman, F.C.
    Phase II antioxidant enzyme activities in brain of male and female ACI rats treated chronically with estradiol (2006), Brain Res., 1104, 80-91.
    View publication on PubMed
Search for more literature for 2.8.2.1

Activating Compound

Activating Compound Comment Organism Structure
additional information estradiol, in constant application, leads to increased SULT1A1 levels in the striatum of rats, correlation of estradiol and SULT1A1 levels, other brain regions like cortex, cerebellum, and hippocampus, are less sensitive Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
SULT1A1 from brain, expression in Escherichia coli strain BL21(DE3) Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus estradiol exhibits neuroprotective action in the brain e.g. by activity of SULT1A1 and other phase II antioxidant enzymes, regulation mechanisms, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P17988 male and female August-Copenhagen Irish, ACI, rats
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Purification (Commentary)

Purification (Comment) Organism
recombinant SULT1A1 from Escherichia coli strain BL21(DE3) cytosol by ammonium sulfate fractionation, anion exchange and adenosine 3',5'-bisphosphate affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain SULT1A1, mainly striatum, lower contents in cortex, hippocampus, and cerebellum Rattus norvegicus
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brain cortex SULT1A1 Rattus norvegicus
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cerebellum SULT1A1 Rattus norvegicus
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hippocampus SULT1A1 Rattus norvegicus
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neuron SULT1A1 Rattus norvegicus
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striatum SULT1A1 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0117 0.0125 SULT1A1, untreated male and female rat striata Rattus norvegicus
0.0199 0.0239 SULT1A1, estradiol-treated male and female rat striata Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information estradiol exhibits neuroprotective action in the brain e.g. by activity of SULT1A1 and other phase II antioxidant enzymes, regulation mechanisms, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
phenol sulfotransferase 1A1
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 Rattus norvegicus
SULT1A1
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 Rattus norvegicus