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Literature summary for 2.8.2.1 extracted from
- Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol (2007), Biochem. Pharmacol., 74, 352-358.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of SULT1A1 in Escherichia coli, expression analysis | Homo sapiens |
| expression of SULT1B1 in Escherichia coli, expression analysis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Aminophenol | substrate inhibition of SULT1A1 | Homo sapiens |  |
| 4-nitrophenol | substrate inhibition of SULT1A1 | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.004 | - |
4-nitrophenol | SULT1A1, pH 7.4, 37°C | Homo sapiens | |
| 0.009 | - |
2-Aminophenol | SULT1A1, pH 7.4, 37°C | Homo sapiens | |
| 0.065 | - |
4-nitrophenol | SULT1B1, pH 7.4, 37°C | Homo sapiens | |
| 0.114 | - |
2-Aminophenol | SULT1B1, pH 7.4, 37°C | Homo sapiens | |
| 0.223 | - |
2-Aminophenol | SULT1A3, pH 7.4, 37°C | Homo sapiens | |
| 0.66 | - |
4-nitrophenol | SULT1A3, pH 7.4, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43704 | SULT1B1 | - |
| Homo sapiens | P0DMM9 | SULT1A3 | - |
| Homo sapiens | P50225 | SULT1A1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | quantitative expression analysis, overview | Homo sapiens | - |
| additional information | no expression of SULT1A3 in adult liver | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
| 0.121 | - |
purified SULT1A1, substrate 2-aminophenol | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 2-aminophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 2-aminophenyl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 2-aminophenol | preferred substrate of SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + 2-aminophenyl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT1A1 | - |
Homo sapiens |
| SULT1A3 | - |
Homo sapiens |
| SULT1B1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.034 | - |
4-nitrophenol | SULT1A1, pH 7.4, 37°C | Homo sapiens | |
| 0.108 | - |
2-Aminophenol | SULT1A1, pH 7.4, 37°C | Homo sapiens | |
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