Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-Dichloro-4-nitrophenol | SULT1A1 is more sensitive than SULT1A3 | Homo sapiens | |
NaCl | SULT1A1 is more sensitive than SULT1A3 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00053 | - |
4-nitrophenol | SULT1A1, pH 7.2, 37°C | Homo sapiens | |
0.0071 | - |
dopamine | SULT1A3, pH 6.5, 37°C | Homo sapiens | |
0.047 | - |
3'-phosphoadenylylsulfate | SULT1A1, pH 7.2, 37°C | Homo sapiens | |
0.07 | - |
3'-phosphoadenylylsulfate | SULT1A3, pH 6.5, 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + a phenol | Homo sapiens | sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
thermostable SULT1A1 and thermolabile SULT1A3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HOS-TE85 cell | osteosarcoma cell line | Homo sapiens | - |
HOS-TE85 cell | predominantly contains SULT1A3 activity | Homo sapiens | - |
osteosarcoma cell | cell lines SaOS-2, U2-OS, PR, and HOS-TE85 | Homo sapiens | - |
osteosarcoma cell line | predominantly contains SULT1A3 activity | Homo sapiens | - |
osteosarcoma cell line | PR cell | Homo sapiens | - |
SAOS-2 cell | osteosarcoma cell line | Homo sapiens | - |
SAOS-2 cell | predominantly contains SULT1A1 activity | Homo sapiens | - |
U2-OS cell | osteosarcoma cell line | Homo sapiens | - |
U2-OS cell | predominantly contains SULT1A1 activity | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + a phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + 4-nitrophenol | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
3'-phosphoadenylylsulfate + a phenol | sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds | Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + bisphenol A | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dopamine | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SULT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
38.3 | - |
SULT1A3, 50% inactivation within 15 min | Homo sapiens |
43 | - |
SULT1A1, 50% inactivation within 15 min | Homo sapiens |
44 | - |
SULT1A3, inactivation within 15 min | Homo sapiens |
47 | - |
SULT1A1, inactivation within 15 min | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
SULT1A3 | Homo sapiens |
7.2 | - |
SULT1A1 | Homo sapiens |