BRENDA - Enzyme Database show
show all sequences of 2.8.2.1

Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases

Sakakibara, Y.; Yanagisawa, K.; Takami, Y.; Nakayama, T.; Suiko, M.; Liu, M.C.; Biochem. Biophys. Res. Commun. 247, 681-686 (1998)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of wild-type P-PST and M-PST and chimeric mutants bearing parts of both enzyme forms in Escherichia coli
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
construction of several chimeric mutants by exchange of sequence fragments between the P-PST and the M-PST form, the structural determinants for the substrate specificity of the 2 forms comprsie the internal domain-spanning amino acid residues 84-148
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics, chimeric enzymes
Homo sapiens
0.00036
-
4-nitrophenol
recombinant wild-type P-PST, pH 7.0, 37°C
Homo sapiens
0.0014
-
dopamine
recombinant wild-type M-PST, pH 7.0, 37°C
Homo sapiens
0.0875
-
dopamine
recombinant wild-type P-PST, pH 7.0, 37°C
Homo sapiens
0.167
-
4-nitrophenol
recombinant wild-type M-PST, pH 7.0, 37°C
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mn2+
stimulates M-PST about 3.5fold, with substrate D-tyrosine
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O43704
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-
Purification (Commentary)
Commentary
Organism
recombinant wild-type P-PST and M-PST and chimeric mutants
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + a phenol
-
645669
Homo sapiens
adenosine 3',5'-bisphosphate + an aryl sulfate
-
645669
Homo sapiens
?
3'-phosphoadenylylsulfate + 4-nitrophenol
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
P-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
i.e. D-Dopa
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + D-tyrosine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
P-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
i.e. L-dopa
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of wild-type P-PST and M-PST and chimeric mutants bearing parts of both enzyme forms in Escherichia coli
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
construction of several chimeric mutants by exchange of sequence fragments between the P-PST and the M-PST form, the structural determinants for the substrate specificity of the 2 forms comprsie the internal domain-spanning amino acid residues 84-148
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics, chimeric enzymes
Homo sapiens
0.00036
-
4-nitrophenol
recombinant wild-type P-PST, pH 7.0, 37°C
Homo sapiens
0.0014
-
dopamine
recombinant wild-type M-PST, pH 7.0, 37°C
Homo sapiens
0.0875
-
dopamine
recombinant wild-type P-PST, pH 7.0, 37°C
Homo sapiens
0.167
-
4-nitrophenol
recombinant wild-type M-PST, pH 7.0, 37°C
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mn2+
stimulates M-PST about 3.5fold, with substrate D-tyrosine
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant wild-type P-PST and M-PST and chimeric mutants
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + a phenol
-
645669
Homo sapiens
adenosine 3',5'-bisphosphate + an aryl sulfate
-
645669
Homo sapiens
?
3'-phosphoadenylylsulfate + 4-nitrophenol
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
P-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
i.e. D-Dopa
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + D-tyrosine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
P-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
i.e. L-dopa
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine
M-PST
645669
Homo sapiens
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
Other publictions for EC 2.8.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737725
Wang
Isozyme specific allosteric re ...
Homo sapiens
Biochemistry
55
4036-4046
2016
-
-
-
-
-
-
1
-
1
-
-
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2
-
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1
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1
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1
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1
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1
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-
738482
Zhang
Sulfation of benzyl alcohol by ...
Homo sapiens
J. Appl. Toxicol.
36
1090-1094
2016
-
-
-
-
-
-
-
-
1
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2
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2
1
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1
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1
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1
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1
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737405
Hartog
-
Substrate engineering and its ...
Desulfitobacterium hafniense
Adv. Synth. Catal.
357
2629-2632
2015
-
-
-
-
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1
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5
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738064
Purchartova
-
Prokaryotic and eukaryotic ary ...
Desulfitobacterium hafniense, Rattus norvegicus
ChemCatChem
7
3152-3162
2015
-
-
2
-
-
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2
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2
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1
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9
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2
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2
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2
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2
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1
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9
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
738167
Van Der Horst
-
Enzymatic sulfation of phenoli ...
Desulfitobacterium hafniense
Eur. J. Org. Chem.
2015
534-541
2015
-
-
1
-
-
-
-
-
-
-
-
1
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1
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1
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8
-
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1
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1
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1
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-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737690
Malojcic
Structural and mechanistic ins ...
Escherichia coli, Escherichia coli CFT073
Biochemistry
53
1870-1877
2014
-
-
-
1
-
-
-
-
-
-
-
2
-
5
-
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2
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1
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2
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2
-
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737962
Ro
-
In vitro metabolic modulation ...
Rattus norvegicus
Bull. Korean Chem. Soc.
35
2577-2580
2014
-
-
-
-
-
-
8
-
1
-
-
-
-
1
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1
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1
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8
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1
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1
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1
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-
-
-
-
-
-
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738063
Ayuso-Fernandez
-
Aryl sulfotransferase from Hal ...
Haliangium ochraceum
ChemCatChem
6
1059-1065
2014
-
-
1
-
-
-
-
2
-
-
1
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1
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1
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1
3
1
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1
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1
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2
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1
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1
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1
3
1
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1
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-
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-
-
-
-
-
-
724077
Purchartova
Enzymatic preparation of silyb ...
Rattus norvegicus
Appl. Microbiol. Biotechnol.
97
10391-10398
2013
1
-
1
-
-
-
-
-
1
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1
1
1
3
-
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1
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2
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3
4
1
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1
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1
1
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1
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2
-
3
4
1
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-
-
-
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-
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724828
Rohn
Potent inhibition of human sul ...
Homo sapiens
Drug Metab. Dispos.
40
1588-1595
2012
-
-
1
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1
1
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2
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2
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1
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2
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3
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1
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3
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724830
Dammanahalli
Oxidative modification of rat ...
Rattus norvegicus
Drug Metab. Dispos.
40
298-303
2012
2
-
1
-
-
-
-
-
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2
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1
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2
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1
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726285
Berger
The molecular basis for the br ...
Homo sapiens
PLoS ONE
6
e26794
2011
-
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1
1
5
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1
1
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2
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1
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3
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1
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5
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1
1
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1
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3
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1
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4
4
726515
Yoshinari
Clioquinol is sulfated by huma ...
Homo sapiens
Toxicol. Lett.
206
229-233
2011
-
-
-
-
-
-
1
-
1
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2
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3
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4
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4
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4
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4
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706669
Yeo
The loss of phenol sulfotransf ...
Homo sapiens
Proteomics
10
266-276
2010
-
1
-
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-
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1
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2
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1
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1
1
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1
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723935
Lu
Spectrofluorometric assay for ...
Homo sapiens
Anal. Biochem.
404
241-243
2010
-
-
-
-
-
-
1
1
-
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2
-
1
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4
-
1
1
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1
1
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1
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-
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-
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-
1
1
1
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2
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4
-
1
1
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1
1
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-
726518
Yu
Functional genetic variants in ...
Homo sapiens
Toxicol. Sci.
118
391-403
2010
-
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3
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1
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702031
Teramoto
Structural basis for the broad ...
Mus musculus
Biochem. Biophys. Res. Commun.
379
76-80
2009
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1
1
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1
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1
1
1
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2
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1
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-
4
-
-
-
-
-
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-
-
-
-
702054
Teramoto
Snapshot of a Michaelis comple ...
Mus musculus
Biochem. Biophys. Res. Commun.
383
83-87
2009
-
-
-
1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702138
Senggunprai
Inhibitory effects of kynureni ...
Homo sapiens, Mus musculus
Biochem. J.
422
455-462
2009
-
-
2
-
-
-
14
10
2
-
-
32
-
4
-
-
2
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32
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26
-
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4
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28
28
-
10
4
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32
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4
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-
-
32
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673308
Furimsky
Effect of resveratrol on 17{be ...
Homo sapiens
Drug Metab. Dispos.
36
129-136
2008
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
5
2
-
1
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1
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1
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1
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-
5
2
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
691593
Murias
Metabolism of resveratrol in b ...
Homo sapiens
Cancer Lett.
261
172-182
2008
-
-
1
-
-
-
1
2
1
-
-
1
-
2
-
-
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-
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2
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2
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-
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3
-
-
1
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3
1
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2
1
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1
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702738
Hattori
Cloning, expression, and chara ...
Drosophila melanogaster
Biosci. Biotechnol. Biochem.
72
540-547
2008
-
-
1
-
-
-
-
6
1
1
5
7
-
3
-
-
1
-
-
-
-
-
7
-
2
-
-
6
1
-
1
-
-
-
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1
-
-
-
-
-
-
-
6
1
1
5
7
-
-
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1
-
-
-
-
7
-
2
-
-
6
1
-
1
-
-
-
-
-
-
-
703487
James
Effects of food natural produc ...
Homo sapiens
Environ. Toxicol. Pharmacol.
25
211-217
2008
-
-
-
-
-
-
2
-
1
-
-
1
-
1
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1
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-
1
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2
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2
2
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705075
Saruwatari
Pomegranate juice inhibits sul ...
Homo sapiens
J. Med. Food
11
623-628
2008
-
-
-
-
-
-
1
-
-
-
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-
6
-
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1
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1
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-
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1
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1
1
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1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
671616
Chodavarapu
Reversible covalent inhibition ...
Bos taurus
Arch. Biochem. Biophys.
457
197-204
2007
-
-
1
-
-
-
4
-
-
-
-
1
-
2
-
-
1
-
-
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3
1
1
-
-
-
1
-
-
-
4
-
-
-
-
1
-
-
-
-
-
4
4
-
-
-
-
1
-
-
-
1
-
-
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671885
Yasuda
Generation and release of nitr ...
Homo sapiens
Biochem. J.
401
497-503
2007
1
-
-
-
-
-
-
7
-
-
-
1
-
2
-
-
-
-
-
3
5
-
6
-
1
-
-
-
2
-
-
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1
-
-
-
-
-
-
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-
-
7
-
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1
-
-
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-
3
5
-
6
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
671926
Riches
Comparison of 2-aminophenol an ...
Homo sapiens
Biochem. Pharmacol.
74
352-358
2007
-
-
1
-
-
-
2
6
1
-
-
-
-
4
-
-
-
-
-
3
2
-
6
-
1
-
-
-
1
-
-
-
2
-
-
-
-
2
-
-
-
-
-
2
2
6
3
-
-
-
-
-
-
-
-
4
4
-
6
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
671928
Itaeaho
Regioselective sulfonation of ...
Homo sapiens
Biochem. Pharmacol.
74
504-510
2007
-
-
1
-
-
-
2
3
-
-
-
1
-
2
-
-
1
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
3
-
-
-
1
-
-
-
1
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672462
Najmanovich
Analysis of binding site simil ...
Homo sapiens
Bioinformatics
23
e104-e109
2007
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
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-
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-
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-
-
-
-
-
-
-
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2
-
-
1
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-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672630
Nishimuta
Inhibitory effects of various ...
Homo sapiens
Biopharm. Drug Dispos.
28
491-500
2007
-
-
1
-
-
-
15
-
1
-
-
4
-
5
-
-
1
-
-
2
-
-
22
-
1
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
29
-
-
2
-
-
4
-
-
-
2
-
2
-
-
22
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
673307
Ung
Variable sulfation of dietary ...
Homo sapiens
Drug Metab. Dispos.
35
740-746
2007
-
-
1
-
-
-
-
12
-
-
-
-
-
2
-
-
-
-
-
-
1
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
1
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
674034
Hempel
Human cytosolic sulfotransfera ...
Homo sapiens
Int. J. Biochem. Cell Biol.
39
685-689
2007
-
-
-
1
1
-
-
-
2
-
-
1
-
2
-
-
-
-
-
1
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675515
Yasuda
Hydroxylated serotonin and dop ...
Homo sapiens
J. Neurochem.
103
2679-2689
2007
-
-
-
-
1
-
2
5
2
-
-
5
-
2
-
-
-
-
-
2
1
-
8
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
5
2
-
-
5
-
-
-
-
-
2
1
-
8
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
675751
Bian
Induction of human sulfotransf ...
Homo sapiens
Life Sci.
81
1659-1667
2007
1
-
1
-
-
-
1
-
-
-
-
3
-
3
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
676745
Allali-Hassani
-
Structural and chemical profil ...
Homo sapiens
PLoS Biol.
5
1063-1078
2007
-
-
-
1
-
-
6
-
1
-
-
1
-
1
-
-
-
1
-
1
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
6
-
-
1
-
-
1
-
-
-
-
-
1
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
677196
Yasuda
Cigarette smoke toxicants as s ...
Homo sapiens
Toxicol. Appl. Pharmacol.
221
13-20
2007
-
-
-
-
-
-
3
-
1
-
-
27
-
7
-
-
-
-
-
5
4
-
53
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
6
-
-
27
-
-
-
-
-
21
17
-
53
-
6
-
-
-
6
-
-
-
-
-
-
-
-
-
677219
Prusakiewicz
Parabens inhibit human skin es ...
Homo sapiens
Toxicology
232
248-256
2007
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671573
Martin-Skilton
Sulfotransferase activities to ...
Lepidorhombus boscii, Mullus barbatus
Aquat. Toxicol.
79
24-30
2006
-
-
-
-
-
-
6
-
-
-
-
5
-
6
-
-
-
-
-
3
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
5
-
-
-
-
-
3
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671776
Assem
Substrate characterisation of ...
Squalius cephalus
Biochem. Biophys. Res. Commun.
349
900-905
2006
-
-
1
-
-
-
-
2
-
-
1
-
-
4
-
-
-
-
-
6
-
-
7
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
6
-
-
7
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672845
Stakhiv
Phase II antioxidant enzyme ac ...
Rattus norvegicus
Brain Res.
1104
80-91
2006
1
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
1
-
-
7
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
7
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672912
Meng
Activation of aminoflavone (NS ...
Homo sapiens
Cancer Res.
66
9656-9664
2006
1
-
-
-
1
-
3
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
3
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
673032
Wang
Polychlorobiphenylols are sele ...
Homo sapiens
Chem. Biol. Interact.
159
235-246
2006
-
-
1
-
-
-
9
1
1
-
-
2
-
3
-
-
-
-
-
1
-
-
12
-
1
-
-
-
1
-
-
-
2
-
16
-
-
2
-
-
-
-
16
18
3
1
2
-
-
2
-
-
-
-
-
2
-
-
12
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
673189
King
Inhibition of human phenol and ...
Homo sapiens
Curr. Drug Metab.
7
745-753
2006
-
-
1
-
-
-
10
1
1
-
-
1
-
3
-
-
-
-
-
1
-
1
1
-
1
-
-
-
1
-
-
-
6
-
9
-
-
1
-
-
-
-
9
10
6
1
1
-
-
1
-
-
-
-
-
1
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
673454
Ohtake
Frequency distribution of phen ...
Homo sapiens
Eur. J. Pharm. Sci.
28
272-277
2006
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
674044
Meinl
Human sulphotransferases are i ...
Homo sapiens
Int. J. Cancer
118
1090-1097
2006
-
-
1
-
-
-
1
-
-
-
-
1
-
7
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676095
Nagar
Sulfotransferase (SULT) 1A1 po ...
Homo sapiens
Mol. Pharmacol.
69
2084-2092
2006
-
-
1
-
-
1
1
-
-
-
-
2
-
2
-
-
1
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
676256
Nowell
Pharmacogenetics of human cyto ...
Homo sapiens
Oncogene
25
1673-1678
2006
-
-
1
-
-
-
-
-
1
-
-
6
-
1
-
-
-
-
-
2
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
2
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677143
Wang
Sulfation of tibolone metaboli ...
Homo sapiens
Steroids
71
343-351
2006
-
-
-
-
-
-
1
3
-
2
-
4
-
3
-
-
-
-
-
2
-
-
8
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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2
-
6
-
4
-
4
-
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-
-
-
4
-
-
8
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
660813
Liu
Identification of a novel zebr ...
Danio rerio
Arch. Biochem. Biophys.
437
10-19
2005
-
-
-
-
-
-
-
-
2
6
1
-
-
6
-
-
1
-
-
2
-
-
11
1
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
6
1
-
-
-
-
1
-
2
-
-
11
1
-
-
2
-
1
1
-
-
-
-
-
-
-
-
660916
Lu
Crystal structure of human sul ...
Homo sapiens
Biochem. Biophys. Res. Commun.
335
417-423
2005
-
-
-
1
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
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-
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3
-
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1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661704
Yasuda
Identification of a novel thyr ...
Danio rerio
FEBS J.
272
3828-3837
2005
-
-
1
-
-
-
7
4
2
1
-
-
-
4
-
-
1
-
-
3
-
-
16
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
4
2
1
-
-
-
-
-
1
-
3
-
-
16
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
661919
Yeh
Induction of phenolsulfotransf ...
Homo sapiens
J. Agric. Food Chem.
53
4766-4773
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
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-
1
-
-
-
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-
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-
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-
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-
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-
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1
-
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-
-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663022
Nishimuta
Inhibitory effects of various ...
Homo sapiens
Pharm. Res.
22
1406-1410
2005
-
1
1
-
-
-
1
2
-
-
-
-
-
4
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
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-
-
-
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-
-
1
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-
-
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1
-
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-
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-
-
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1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660962
Tsoi
Amino acid residue 247 in cani ...
Canis lupus familiaris
Biochem. J.
378
687-692
2004
-
-
1
-
4
-
2
6
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
6
-
-
-
-
3
-
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-
1
-
-
4
-
-
2
3
6
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
661028
Chen
Histidine residues in human ph ...
Homo sapiens
Biochem. Pharmacol.
67
1355-1361
2004
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
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-
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-
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-
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-
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-
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-
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1
-
-
-
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-
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661470
Sohlenius-Sternbeck
Characterization of the rates ...
Rattus norvegicus
Chem. Biol. Interact.
148
49-56
2004
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
17
-
-
-
-
-
-
-
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-
-
-
-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661580
Nakano
Regioselective monosulfation a ...
Homo sapiens
Drug Metab. Pharmacokinet.
19
216-226
2004
-
-
-
-
-
-
-
22
2
-
-
1
-
2
-
-
-
-
-
2
-
-
17
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
22
2
-
-
1
-
-
-
-
-
2
-
-
17
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
661915
Yeh
Synergistic effect of antioxid ...
Homo sapiens
J. Agric. Food Chem.
52
4139-4143
2004
1
-
-
-
-
-
-
-
-
-
-
-
-
2
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1
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1
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-
1
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-
-
-
-
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-
-
-
-
-
-
-
-
-
662207
Barnett
Active site mutations and subs ...
Homo sapiens
J. Biol. Chem.
279
18799-18805
2004
-
-
-
-
2
-
3
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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4
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-
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-
4
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-
-
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-
-
-
-
-
-
-
-
-
662510
Novakova
Study of enzyme kinetics of ph ...
Homo sapiens
J. Chromatogr. A
1032
319-326
2004
-
-
-
-
-
-
2
1
1
-
-
-
-
1
-
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-
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1
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1
-
1
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-
-
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-
-
-
-
-
-
-
-
-
662515
Ebmeier
Human thyroid phenol sulfotran ...
Homo sapiens
J. Clin. Endocrinol. Metab.
89
5597-5605
2004
-
-
-
-
-
-
4
4
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
4
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
662758
Lin
Molecular cloning and function ...
Sus scrofa
Mamm. Genome
15
218-226
2004
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
10
-
-
1
-
-
-
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-
-
-
-
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-
1
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1
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10
-
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1
-
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-
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-
-
663431
Davies
Effects of culture with TNF-al ...
Homo sapiens
Toxicol. In Vitro
18
749-754
2004
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
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4
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5
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4
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5
-
-
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-
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-
-
-
-
-
-
645681
Tabrett
Phenol sulfotransferase 1A1 ac ...
Homo sapiens
Biochem. Pharmacol.
66
2089-2097
2003
-
-
-
-
-
-
-
1
2
-
-
1
-
2
-
-
-
-
-
3
1
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4
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1
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1
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2
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1
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-
3
1
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645685
Chen
Arginine residues in the activ ...
Homo sapiens
J. Biol. Chem.
278
36358-36364
2003
-
-
1
-
8
-
1
1
1
-
-
-
-
2
-
-
1
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
8
-
-
1
-
1
1
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645686
Yeh
Effects of phenolic acids on h ...
Homo sapiens
J. Agric. Food Chem.
51
1474-1479
2003
7
-
-
-
-
-
6
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
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7
-
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6
-
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1
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1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645687
Sugahara
Differential roles of human mo ...
Homo sapiens
J. Biochem.
133
259-262
2003
-
-
-
-
-
-
6
3
1
1
-
2
-
1
-
-
-
-
-
-
3
-
18
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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6
-
3
1
1
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2
-
-
-
-
-
-
3
-
18
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645682
Tsoi
Canine sulfotransferase SULT1A ...
Canis lupus familiaris
Arch. Biochem. Biophys.
401
125-133
2002
-
-
1
-
-
-
2
6
1
-
-
-
-
6
-
-
1
-
-
9
-
-
9
-
-
-
-
-
2
-
-
-
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1
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2
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6
1
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1
-
9
-
-
9
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
645683
Riley
Isolation and characterisation ...
Oryctolagus cuniculus
Int. J. Biochem. Cell Biol.
34
958-969
2002
-
-
-
-
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-
-
-
-
-
-
-
-
1
-
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645684
Pai
Manganese stimulation and ster ...
Homo sapiens
J. Biol. Chem.
277
43813-43820
2002
-
-
1
-
1
-
-
1
-
1
-
-
-
2
-
-
-
1
-
-
4
-
8
-
-
-
-
-
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1
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1
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1
-
1
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-
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-
4
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645678
Dubin
Thermostable (SULT1A1) and the ...
Homo sapiens
Bone
28
617-624
2001
-
-
-
-
-
-
2
4
-
-
-
1
-
2
-
-
-
-
-
5
-
-
5
-
1
-
4
-
2
-
-
-
-
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-
-
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2
-
4
-
-
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1
-
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-
-
5
-
-
5
-
1
-
4
-
2
-
-
-
-
-
-
-
-
-
645679
Li
Characterization of human live ...
Homo sapiens
J. Endocrinol.
171
525-532
2001
-
-
1
-
-
-
-
8
-
-
-
-
-
2
-
-
-
-
-
2
-
-
8
-
1
-
2
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
2
-
-
8
-
1
-
2
-
1
-
-
-
-
-
-
-
-
-
645680
Honma
Enzymatic characterization and ...
Homo sapiens, Mus musculus, Mus musculus BALB/c, Mus musculus ST1a4, Oryctolagus cuniculus, Oryctolagus cuniculus ST1A8, Rattus norvegicus
Drug Metab. Dispos.
29
274-281
2001
-
-
4
-
-
-
1
16
-
-
-
-
-
70
-
-
-
-
-
1
4
-
127
-
4
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
16
-
-
-
-
-
-
-
-
-
1
4
-
127
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
645688
Duffel
Enzymatic aspects of the pheno ...
Bos taurus, Canis lupus familiaris, Homo sapiens, Macaca fascicularis, Macaca fascicularis ST1A9, Mus musculus, Mus musculus ST1a4, Mus musculus ST1c4, Oryctolagus cuniculus, Oryctolagus cuniculus ST1A8, Oryctolagus cuniculus ST1C5, Rattus norvegicus
Drug Metab. Rev.
33
369-395
2001
2
-
-
-
-
-
7
7
2
-
-
3
-
27
1
-
-
7
-
4
-
-
162
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
7
-
18
3
-
-
3
-
1
-
-
-
5
-
-
162
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
645672
Marshall
Redox control of aryl sulfotra ...
Rattus norvegicus
Arch. Biochem. Biophys.
382
95-104
2000
1
-
-
-
-
-
-
1
1
-
-
-
-
2
1
-
-
1
-
1
-
-
5
-
1
-
-
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
1
-
-
5
-
1
-
-
-
2
1
-
-
-
-
-
-
-
-
645673
Tong
Purification and characterizat ...
Ictalurus punctatus
Arch. Biochem. Biophys.
376
409-419
2000
-
-
-
-
-
-
1
7
1
-
1
-
-
5
-
-
1
-
-
4
-
-
9
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
7
1
-
1
-
-
-
-
1
-
4
-
-
9
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645674
Liu
Mutational analysis of the sub ...
Homo sapiens
J. Biol. Chem.
275
13460-13464
2000
-
-
1
-
17
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645675
Suiko
Sulfation of environmental est ...
Homo sapiens
Biochem. Biophys. Res. Commun.
267
80-84
2000
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
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-
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-
2
4
-
14
-
1
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-
-
1
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-
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-
-
-
-
-
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1
-
-
1
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-
-
2
4
-
14
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645676
Lin
Nucleotide binding and sulfati ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
271
818-822
2000
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
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5
-
1
-
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-
1
-
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2
-
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-
2
-
-
-
-
-
-
5
-
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-
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-
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-
-
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-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645677
Harris
Sulfation of 'estrogenic' alky ...
Homo sapiens
J. Biol. Chem.
275
159-166
2000
-
-
-
-
-
-
11
1
2
-
-
-
-
2
-
-
-
-
-
2
-
-
14
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
11
3
1
2
-
-
-
-
-
-
-
-
2
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645670
Dajani
Kinetic properties of human do ...
Homo sapiens
Protein Expr. Purif.
16
11-18
1999
-
-
1
-
1
-
-
3
-
-
-
-
-
4
-
-
1
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645671
Dajani
X-ray crystal structure of hum ...
Homo sapiens
J. Biol. Chem.
274
37862-37868
1999
-
-
-
1
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
22
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
22
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645667
Yang
Effects of 3'-phosphoadenosine ...
Rattus norvegicus
Chem. Biol. Interact.
109
129-135
1998
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
1
-
-
-
3
1
-
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
3
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
645668
Dajani
A single amino acid, Glu146, g ...
Homo sapiens
Mol. Pharmacol.
54
942-948
1998
-
-
1
-
3
-
-
15
-
-
-
-
-
3
-
-
1
1
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
15
-
-
-
-
-
-
-
2
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645669
Sakakibara
Molecular cloning, expression, ...
Homo sapiens
Biochem. Biophys. Res. Commun.
247
681-686
1998
-
-
1
-
1
-
-
5
-
1
-
-
-
3
-
-
1
-
-
-
-
-
12
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
5
-
1
-
-
-
-
-
1
-
-
-
-
12
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645666
Hwang
High level expression and char ...
Homo sapiens
Protein Expr. Purif.
11
125-134
1997
-
-
1
-
-
-
-
1
-
-
2
-
-
4
-
-
1
-
-
4
1
-
5
1
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
4
1
-
5
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
645665
Yang
Two phenol sulfotransferase sp ...
Rattus norvegicus
Protein Expr. Purif.
8
423-429
1996
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
645662
Kudlacek
Characterization of recombinan ...
Homo sapiens
Biochem. Biophys. Res. Commun.
210
363-369
1995
-
-
-
-
-
-
2
3
-
-
-
2
-
2
-
-
-
-
-
4
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
-
2
-
-
-
-
-
4
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645663
Sakakibara
Purification, characterization ...
Rattus norvegicus
J. Biol. Chem.
270
30470-30478
1995
-
-
1
-
-
-
1
4
1
-
1
-
-
2
-
-
1
-
-
2
1
-
11
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
4
1
-
1
-
-
-
-
1
-
2
1
-
11
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645664
Ganguly
Bacterial expression and kinet ...
Homo sapiens
Drug Metab. Dispos.
23
945-950
1995
-
-
1
-
-
-
-
-
1
-
1
-
-
3
-
-
-
-
-
6
-
-
13
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
6
-
-
13
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
644824
Saidha
Purification and properties of ...
Euglena gracilis
Biochem. J.
298
45-50
1994
-
-
-
-
-
-
2
6
-
-
-
-
-
3
-
-
1
-
-
1
1
-
11
-
1
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
6
-
-
-
-
-
-
-
1
-
1
1
-
11
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645643
Bartzatt
Inhibition of phenol sulfotran ...
Bos taurus
Biochem. Pharmacol.
47
2087-2095
1994
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645644
Seah
2,6-Dichloro-4-nitrophenol (DC ...
Rattus norvegicus
Biochem. Pharmacol.
47
1743-1749
1994
-
-
-
-
-
-
2
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
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-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645655
Veronese
Functional characterization of ...
Homo sapiens
Biochem. J.
302
497-502
1994
-
-
1
-
-
-
1
4
1
-
-
-
-
3
-
-
-
-
-
4
-
-
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
4
1
-
-
-
-
-
-
-
-
4
-
-
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
645659
Wood
Human liver thermolabile pheno ...
Homo sapiens
Biochem. Biophys. Res. Commun.
198
1119-1127
1994
-
-
1
-
-
-
-
-
-
-
1
1
-
2
-
-
1
-
-
4
-
-
5
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
4
-
-
5
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
645660
Falany
Characterization of expressed ...
Homo sapiens
Chem. Biol. Interact.
92
57-66
1994
-
-
1
-
1
-
-
1
1
-
-
1
-
3
-
-
-
1
-
5
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
1
-
-
1
-
-
-
-
-
5
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645645
Fernando
Isolation and characterization ...
Bos taurus
Biochem. Mol. Biol. Int.
30
433-441
1993
-
-
-
-
-
-
2
-
3
-
-
-
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
645646
Rao
Benzylic alcohols as stereospe ...
Rattus norvegicus
Chirality
3
104-111
1991
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645657
Falany
Purification and characterizat ...
Homo sapiens
Arch. Biochem. Biophys.
278
312-318
1990
-
-
-
-
-
-
2
-
2
-
2
-
-
2
-
-
1
-
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645647
Pacifici
Characterization of sulphotran ...
Homo sapiens
Pharmacology
38
146-150
1989
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645653
Weinshilboum
Phenol sulfotransferase in hum ...
Homo sapiens
Fed. Proc.
45
2223-2228
1986
-
-
-
-
-
-
3
1
-
1
-
-
-
2
-
-
1
-
-
2
1
-
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
1
-
-
-
-
-
1
-
2
1
-
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
645656
Whittemore
Purification and kinetic chara ...
Homo sapiens
Arch. Biochem. Biophys.
249
464-471
1986
-
-
-
-
-
-
3
2
-
-
-
-
-
2
-
-
1
1
-
2
1
-
1
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
3
1
2
-
-
-
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
645658
Whittemore
Purification and kinetic chara ...
Homo sapiens
Biochemistry
24
2477-2482
1985
-
-
-
-
-
-
3
2
-
-
1
-
-
2
-
-
1
1
-
2
2
-
5
-
1
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
2
2
-
-
1
-
-
-
-
1
-
2
2
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
645641
Romain
Partial purification and chara ...
Canis lupus familiaris
Biochem. Biophys. Res. Commun.
106
999-1005
1982
1
-
-
-
-
-
5
4
-
1
1
-
-
1
-
-
1
-
-
1
2
-
8
-
1
-
-
-
4
1
-
-
-
-
-
1
-
-
-
-
-
-
-
5
-
4
-
1
1
-
-
-
-
1
-
1
2
-
8
-
1
-
-
-
4
1
-
-
-
-
-
-
-
-
645649
Rein
Multiple forms of phenolsulpho ...
Homo sapiens
Biochem. Pharmacol.
31
1893-1897
1982
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
644825
Sekura
Aryl sulfotransferases ...
Rattus norvegicus
Methods Enzymol.
77
197-206
1981
-
-
-
-
-
1
2
-
-
3
3
-
-
1
-
-
1
-
-
1
2
2
6
1
1
-
-
9
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
3
3
-
-
-
-
1
-
1
2
2
6
1
1
-
-
9
2
-
-
-
-
-
-
-
-
-
645648
Baranczyk-Kuzma
-
Phenol sulfotransferases: puri ...
Rattus norvegicus
Phenolsulfotransferase, Ment. Health Res. (Sandler, M. , Usdin, E. Eds. ) Macmillan
London
55-73
1981
-
-
-
-
-
-
2
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
645651
Roth
-
Characterization of human brai ...
Homo sapiens
Phenolsulfotransferase, Ment. Health Res. (Sandler, M. , Usdin, E. Eds. ) Macmillan
London
74-85
1981
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645642
Sekura
Phenol sulfotransferases ...
Rattus norvegicus
J. Biol. Chem.
254
5658-5663
1979
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645650
Pennings
Inhibition of rat brain phenol ...
Rattus norvegicus
J. Neurochem.
27
915-920
1976
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645654
Foldes
Rat brain phenolsulfotransfera ...
Rattus norvegicus
Biochim. Biophys. Acta
327
365-374
1973
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