Literature summary for 2.8.1.8 extracted from

Cicchillo, R.M.; Iwig, D.F.; Jones, A.D.; Nesbitt, N.M.; Baleanu-Gogonea, C.; Souder, M.G.; Tu, L.; Booker, S.J.
Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid (2004), Biochemistry, 43, 6378-6386.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine	lipoyl-bearing subunit of the glycine cleavage system (H-protein) is a substrate for LipA. 5'-deoxyadenosyl radical acts directly on the octanoyl substrate. 2 equivalents of S-adenosyl-L-methionine are cleaved irreversibly in forming 1 equivalent of [lipoyl]H-protein and are consistent with a model in which two LipA proteins are required to synthesize one lipoyl group	Escherichia coli	protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosyl radicals	-	ir

Synonyms

Synonyms	Comment	Organism
LipA	-	Escherichia coli

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Release 2023.1 (January 2023)