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Literature summary for 2.8.1.7 extracted from

  • Giordano, N.; Hastie, J.; Smith, A.; Foss, E.; Gutierrez-Munoz, D.; Carlson, P.J.
    Cysteine desulfurase IscS2 plays a role in oxygen resistance in Clostridium difficile (2018), Infect. Immun., 86, e00326 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Clostridioides difficile Q18BE4
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Clostridioides difficile 630 Q18BE4
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Synonyms

Synonyms Comment Organism
CD630_12790
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 Clostridioides difficile
IscS2
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 Clostridioides difficile

General Information

General Information Comment Organism
physiological function deletion of isoform causes a severe growth defect in the presence of 2% oxygen. The mutation delays colonization in a conventional mouse model of Clostridioides difficile infection and fails to colonize in a germfree model, which has higher intestinal oxygen levels Clostridioides difficile