Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.1.7 extracted from

  • Wang, J.; Guo, X.; Li, H.; Qi, H.; Qian, J.; Yan, S.; Shi, J.; Niu, W.
    Hydrogen sulfide from cysteine desulfurase, not 3-mercaptopyruvate sulfurtransferase, contributes to sustaining cell growth and bioenergetics in E. coli under anaerobic conditions (2019), Front. Microbiol., 10, 2357 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.1.7

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Synonyms

Synonyms Comment Organism
cysteine desulfurase
-
 Escherichia coli
IcsS
-
 Escherichia coli

General Information

General Information Comment Organism
physiological function cysteine desulfurase (IscS, EC 2.8.1.7), not 3-MST, is the primary source of endogenous H2S in Escherichia coli under anaerobic conditions. A significant decrease in H2S production under anaerobic conditions is observed in Escherichia coli upon deletion of IscS, but not in 3-MST-deficient bacteria. The H2S-producing activity of recombinant IscS using L-cysteine as a substrate exhibits an approximately 2.6fold increase in the presence of dithiothreitol. The activity of IscS is regulated under the different redox conditions and the midpoint redox potential is -329 mV. H2S production from IscS is regulated under oxidative and reductive stress. A mutant strain lacking a chromosomal copy of the IscS-encoding gene iscS shows significant growth defects and low levels of ATP under both aerobic and anaerobic conditions Escherichia coli