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Literature summary for 2.8.1.7 extracted from

  • Rybniker, J.; Pojer, F.; Marienhagen, J.; Kolly, G.S.; Chen, J.M.; van Gumpel, E.; Hartmann, P.; Cole, S.T.
    The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence (2014), Biochem. J., 459, 467-478.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + acceptor Mycobacterium tuberculosis
-
 L-alanine + S-sulfanyl-acceptor
-
 ?
L-cysteine + acceptor Mycobacterium tuberculosis Rv3025c
-
 L-alanine + S-sulfanyl-acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis Rv3025c
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + acceptor
-
 Mycobacterium tuberculosis L-alanine + S-sulfanyl-acceptor
-
 ?
L-cysteine + acceptor
-
 Mycobacterium tuberculosis Rv3025c L-alanine + S-sulfanyl-acceptor
-
 ?

Synonyms

Synonyms Comment Organism
IscS
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction deleting the enzyme renders the cells microaerophilic and hypersensitive to oxidative stress. Moreover, the deletion mutant shows impaired Fe-S cluster-dependent enzyme activity Mycobacterium tuberculosis
physiological function the enzyme is involved in iron-sulfur cluster biogenesis and oxidative stress defence Mycobacterium tuberculosis