Literature summary for 2.8.1.7 extracted from

Hidese, R.; Mihara, H.; Esaki, N.
Bacterial cysteine desulfurases: versatile key players in biosynthetic pathways of sulfur-containing biofactors (2011), Appl. Microbiol. Biotechnol., 91, 47-61.

Search for more literature for 2.8.1.7

Organism

Organism	UniProt	Comment	Textmining
Azotobacter vinelandii	-	-	-
Bacillus subtilis	-	-	-
Escherichia coli	-	-	-
Helicobacter pylori	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-cysteine + [enzyme]-cysteine	-	Bacillus subtilis	L-alanine + [enzyme]-S-sulfanylcysteine	-	?
L-cysteine + [enzyme]-cysteine	-	Escherichia coli	L-alanine + [enzyme]-S-sulfanylcysteine	-	?
L-cysteine + [enzyme]-cysteine	-	Saccharomyces cerevisiae	L-alanine + [enzyme]-S-sulfanylcysteine	-	?
L-cysteine + [enzyme]-cysteine	-	Azotobacter vinelandii	L-alanine + [enzyme]-S-sulfanylcysteine	-	?
L-cysteine + [enzyme]-cysteine	-	Helicobacter pylori	L-alanine + [enzyme]-S-sulfanylcysteine	-	?
L-cysteine + [ThiI]-cysteine	-	Escherichia coli	L-alanine + [ThiI]-S-sulfanylcysteine	-	?
additional information	IscS is essential for Fe-S cluster assembly in vivo	Escherichia coli	?	-	?
additional information	Nfs1 mediates assembly of the Fe-S cluster of both mitochondrial and cytosolic Fe-S proteins in the mitochondrial Fe-S assembly system	Saccharomyces cerevisiae	?	-	?
additional information	NifS specifically mobilizes sulfur for the iron-sulfur (Fe-S) cluster maturation of nitrogenase	Azotobacter vinelandii	?	-	?
additional information	the enzyme is capable of donating the persulfide sulfur atoms to a variety of biosynthetic pathways for sulfur-containing biofactors, such as iron-sulfur clusters, thiamin, transfer RNA thionucleosides, biotin, and lipoic acid	Escherichia coli	?	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Bacillus subtilis
homodimer	-	Escherichia coli
homodimer	-	Saccharomyces cerevisiae
homodimer	-	Azotobacter vinelandii
homodimer	-	Helicobacter pylori

Synonyms

Synonyms	Comment	Organism
CsdA	-	Escherichia coli
CsdB	-	Escherichia coli
IscS	-	Escherichia coli
Nfs1	-	Saccharomyces cerevisiae
NIFS	-	Azotobacter vinelandii
NIFS	-	Helicobacter pylori
SufS	-	Bacillus subtilis
SufS	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	dependent on	Bacillus subtilis
pyridoxal 5'-phosphate	dependent on	Escherichia coli
pyridoxal 5'-phosphate	dependent on	Saccharomyces cerevisiae
pyridoxal 5'-phosphate	dependent on	Azotobacter vinelandii
pyridoxal 5'-phosphate	dependent on	Helicobacter pylori

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Release 2023.1 (January 2023)