Literature summary for 2.8.1.7 extracted from

Canal, F.; Fosset, C.; Chauveau, M.J.; Drapier, J.C.; Bouton, C.
Regulation of the cysteine desulfurase Nfs1 and the scaffold protein IscU in macrophages stimulated with interferon-gamma and lipopolysaccharide (2007), Arch. Biochem. Biophys., 465, 282-292.

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Inhibitors

Inhibitors	Comment	Organism	Structure
interferon-gamma	downregulation of cysteine desulfurase and its protein partner IscU at both mRNA and protein level by stimulation of macrophages with interferon-gamma; the cysteine desulfurase Nfs1 and its scaffold protein partner IscU are down-regulated at both mRNA and protein levels when murine macrophages are physiologically stimulated with interferon-gamma	Mus musculus
lipopolysaccharide	downregulation of enzyme at both mRNA and protein level by stimulation of macrophages with lipopolysaccharide. Lipopolysaccharide triggers a delayed decline of cysteine desulfurase protein and its protein partner IscU; LPS triggers a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability, also the expression of IscU is down-regulated in LPS-stimulated macrophages	Mus musculus
additional information	exposure of cells to exogenous sources of NO does not alter Nfs1 expression; exposure of macrophages to exogenous sources of nitric oxide does not alter enzyme expression	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	enzyme isoform Nfs1	Mus musculus	-
macrophage	mitochondrial isoform of Nfs1	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cysteine desulfurase	-	Mus musculus
Nfs1	-	Mus musculus

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Release 2023.1 (January 2023)