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Literature summary for 2.8.1.7 extracted from

  • Lauhon, C.T.; Kambampati, R.
    The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD (2000), J. Biol. Chem., 275, 20096-20103.
    View publication on PubMed
Search for more literature for 2.8.1.7

Protein Variants

Protein Variants Comment Organism
additional information deletion of the iscS gene results in a mutant strain that lacks 4-thiouridine in its tRNA Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + [enzyme]-cysteine Escherichia coli
-
 L-alanine + [enzyme]-S-sulfanylcysteine
-
 ?
L-cysteine + [enzyme]-cysteine Escherichia coli MC1061
-
 L-alanine + [enzyme]-S-sulfanylcysteine
-
 ?
additional information Escherichia coli IscS plays a significant and specific role at the top of a potentially broad sulfur transfer cascade that is required for the biosynthesis of thiamine, NAD, [Fe-S] clusters and thionucleosides ?
-
 ?
additional information Escherichia coli acts as sulfurtransferase in biosynthesis of 4-thiouridine in tRNA ?
-
 ?
additional information Escherichia coli MC1061 IscS plays a significant and specific role at the top of a potentially broad sulfur transfer cascade that is required for the biosynthesis of thiamine, NAD, [Fe-S] clusters and thionucleosides ?
-
 ?
additional information Escherichia coli MC1061 acts as sulfurtransferase in biosynthesis of 4-thiouridine in tRNA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 MC1061
-
Escherichia coli MC1061
-
 MC1061
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + [enzyme]-cysteine
-
 Escherichia coli L-alanine + [enzyme]-S-sulfanylcysteine
-
 ?
L-cysteine + [enzyme]-cysteine
-
 Escherichia coli MC1061 L-alanine + [enzyme]-S-sulfanylcysteine
-
 ?
additional information IscS plays a significant and specific role at the top of a potentially broad sulfur transfer cascade that is required for the biosynthesis of thiamine, NAD, [Fe-S] clusters and thionucleosides Escherichia coli ?
-
 ?
additional information acts as sulfurtransferase in biosynthesis of 4-thiouridine in tRNA Escherichia coli ?
-
 ?
additional information IscS plays a significant and specific role at the top of a potentially broad sulfur transfer cascade that is required for the biosynthesis of thiamine, NAD, [Fe-S] clusters and thionucleosides Escherichia coli MC1061 ?
-
 ?
additional information acts as sulfurtransferase in biosynthesis of 4-thiouridine in tRNA Escherichia coli MC1061 ?
-
 ?