Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acidomycin | acidomycin inhibits biotin synthesis through the competitive inhibition of biotin synthase BioB and also stimulates unproductive cleavage of S-adenosyl-L-methionine to generate the toxic metabolite 5'-deoxyadenosine. Acidomycin selectively accumulates in Mycobycterium tuberculosis. The development of spontaneous resistance by Mycobacterium tuberculosis to acidomycin is difficult, and only low-level resistance to acidomycin is observed by overexpression of BioB | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WPQ7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WPQ7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
BioB | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
acidomycin | approximate value, pH 8.0, 37°C | Mycobacterium tuberculosis |