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Literature summary for 2.8.1.2 extracted from

  • Abdollahi Govar, A.; Toero, G.; Szaniszlo, P.; Pavlidou, A.; Bibli, S.I.; Thanki, K.; Resto, V.A.; Chao, C.; Hellmich, M.R.; Szabo, C.; Papapetropoulos, A.; Modis, K.
    3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics (2020), Br. J. Pharmacol., 177, 866-883 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P25325
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Source Tissue

Source Tissue Comment Organism Textmining
EAhy 926 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function attenuation of 3MST by shRNA or pharmacological inhibition of 3MST significantly reduces endothelial cell proliferation,migration, and tube-like network formation. 3MST silencing also suppresses VEGF-induced endothelial cell migration. 3MST attenuation decreases mitochondrial respiration and mitochondrial ATP production, increases glucose uptake, and perturbes the entire endothelia cell metabolome Homo sapiens