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Literature summary for 2.8.1.2 extracted from
- Role of 3-mercaptopyruvate sulfurtransferase in the regulation of proliferation and cellular bioenergetics in human Down syndrome fibroblasts (2020), Biomolecules, 10, 653 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a significantly higher level of 3-MST protein expression is observed in Down syndrome (trisomy of human chromosome 21) fibroblasts compared to cells from healthy control individuals. The excess 3-MST is mainly localized to the mitochondrial compartment. Pharmacological inhibition of 3-MST activity improves mitochondrial electron transport and oxidative phosphorylation parameters and enhances cell proliferation in Down syndrome cells but not in healthy control cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P25325 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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