Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.54 | - |
3-Mercaptopyruvate | isoform TUM1-Iso2, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
0.55 | - |
3-Mercaptopyruvate | isoform TUM1-Iso1, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
1.29 | - |
3-Mercaptopyruvate | isoform TUM1-Iso2, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
1.33 | - |
3-Mercaptopyruvate | isoform TUM1-Iso1, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
2.59 | - |
dithiothreitol | isoform TUM1-Iso2, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
2.69 | - |
dithiothreitol | isoform TUM1-Iso1, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
4.45 | - |
cyanide | isoform TUM1-Iso1, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
4.5 | - |
cyanide | isoform TUM1-Iso2, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform TUM1-Iso1 and TUM1-Iso2 | Homo sapiens | 5829 | - |
mitochondrion | isoforms TUM1-Iso2 | Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
x * 25000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-mercaptopyruvate + cyanide | Homo sapiens | - |
pyruvate + thiocyanate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P25325 | - |
- |
Purification (Comment) | Organism |
---|---|
glutathione-agarose column chromatography and benzamidine Sepharose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-mercaptopyruvate + cyanide | - |
Homo sapiens | pyruvate + thiocyanate | - |
? | |
3-mercaptopyruvate + dithiothreitol | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
3-mercaptopyruvate:cyanide sulfurtransferase | - |
Homo sapiens |
MPST | - |
Homo sapiens |
TUM1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
49 | - |
- |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8.6 | - |
3-Mercaptopyruvate | isoform TUM1-Iso2, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
8.8 | - |
3-Mercaptopyruvate | isoform TUM1-Iso1, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
20.2 | - |
3-Mercaptopyruvate | isoform TUM1-Iso2, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
20.9 | - |
3-Mercaptopyruvate | isoform TUM1-Iso1, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10.5 | - |
- |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme interacts with proteins involved in Moco and FeS cluster biosynthesis like L-cysteine desulfurase NFS1 and the rhodanese-like protein MOCS3 | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.9 | - |
cyanide | isoform TUM1-Iso2, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
2 | - |
cyanide | isoform TUM1-Iso1, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
6.6 | - |
3-Mercaptopyruvate | isoform TUM1-Iso1, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
6.7 | - |
3-Mercaptopyruvate | isoform TUM1-Iso2, with cyanide as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
7.7 | - |
dithiothreitol | isoform TUM1-Iso2, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
7.8 | - |
dithiothreitol | isoform TUM1-Iso1, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
38.2 | - |
3-Mercaptopyruvate | isoform TUM1-Iso1, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens | |
38.2 | - |
3-Mercaptopyruvate | isoform TUM1-Iso2, with dithiothreitol as cosubstrate, at pH 10.5 and 37°C | Homo sapiens |