Literature summary for 2.8.1.12 extracted from

Sloan, J.; Kinghorn, J.R.; Unkles, S.E.
The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames (1999), Nucleic Acids Res., 27, 854-858.

Search for more literature for 2.8.1.12

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, cDNA clones ATCC 960768 from adult uterus and ATCC 331184 from fetal liver and spleen, the MOCO1 locus resides on human chromosome 5 encoding subunits MOCO1-A and MOCO1-B	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
9700	-	2 * 9700, subunit MOCO1-A, + 2 * 20900, subunit MOCO1-B, SDS-PAGE	Homo sapiens
20900	-	2 * 9700, subunit MOCO1-A, + 2 * 20900, subunit MOCO1-B, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O96007	-	-

Subunits

Subunits	Comment	Organism
heterotetramer	2 * 9700, subunit MOCO1-A, + 2 * 20900, subunit MOCO1-B, SDS-PAGE	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	molybdopterin synthase is involved in the conversion of precursor Z to molybdopterin in the molybdenum cofactor biosynthetic pathway	Homo sapiens
physiological function	the small and large subunits in humans, MOCO1-A and MOCO1-B, respectively, together form molybdopterin synthase which adds sulphur to precursor Z	Homo sapiens

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Release 2023.1 (January 2023)