Literature summary for 2.8.1.10 extracted from

Dorrestein, P.C.; Zhai, H.; Taylor, S.V.; McLafferty, F.W.; Begley, T.P.
The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase (2004), J. Am. Chem. Soc., 126, 3091-3096.

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Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	O31618	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O	mechanism involves the generation of a ketone at C3 of 1-deoxy-D-xylulose-5-phosphate by an Amadori-type rearrangement of the imine followed by nucleophillic addition of the sulfur carrier protein to this carbonyl group	Bacillus subtilis	a

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Release 2023.1 (January 2023)