Literature summary for 2.8.1.1 extracted from

Pavlovskiy, Y.; Yashchenko, A.; Zayachkivska, O.
H2S donors reverse age-related gastric malfunction impaired due to fructose-induced injury via CBS, CSE, and TST expression (2020), Front. Pharmacol., 11, 1134 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
4-carbamothioylphenyl 2-(acetyloxy)benzoate	i.e. H2S-releasing aspirin, ATB-340. Pretreatment by H2S donors NaHS and 4-carbamothioylphenyl 2-(acetyloxy)benzoate in aged rats reduces the oxidative index levels and correlate with thiosulfate-dithiol sulfurtransferase activity	Rattus norvegicus

Application

Application	Comment	Organism
medicine	adult rats on high fructose diet have 56% decrease in thiosulfate-dithiol sulfurtransferase activity, 35% decrease in cystathionine beta synthase and 48% decrease in cystathionine gamma synthase activity, compared to a standard diet group. Aged rats on high fructose diet have lower activities of all three enzymes versus aged rats on standard diet. Increased activities of all H2S-related enzymes are oberved during induction of acute water immersion restraint stress. In adult rats exposed to stress on high fructose diet and treatment by NaHS, 1.8 times increased activities of cystathionine beta synthase, 1.3 times increased activities of cystathionine gamma synthase, and 69% increased activities of thiosulfate-dithiol sulfurtransferase are seen over adult rats with vehicle. Rats fed by high fructose diet have higher levels of the oxidative index than animals fed by standard diet. The pretreatment by H2S donors NaHS and 4-carbamothioylphenyl 2-(acetyloxy)benzoate in aged rats reduces the oxidative index levels and correlate with thiosulfate-dithiol sulfurtransferase activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P24329	-	-

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Release 2023.1 (January 2023)