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Literature summary for 2.8.1.1 extracted from

  • Witholt, S.J.; Sankaranarayanan, R.; Garen, C.R.; Cherney, M.M.; Cherney, L.T.; James, M.N.
    Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis (2008), Acta Crystallogr. Sect. F, 64, 541-544.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.1.1

Application

Application Comment Organism
pharmacology target for developing a tuberculosis drug Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expression of His6-Rv3117 in Escherichia coli BL21-DE3 Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapour-diffusion method Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thiosulfate + cyanide Mycobacterium tuberculosis thiocyanate is less toxic than cyanide sulfite + thiocyanate
-
 ?
thiosulfate + cyanide Mycobacterium tuberculosis H37Rv thiocyanate is less toxic than cyanide sulfite + thiocyanate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thiosulfate + cyanide
-
 Mycobacterium tuberculosis sulfite + thiocyanate
-
 ?
thiosulfate + cyanide thiocyanate is less toxic than cyanide Mycobacterium tuberculosis sulfite + thiocyanate
-
 ?
thiosulfate + cyanide
-
 Mycobacterium tuberculosis H37Rv sulfite + thiocyanate
-
 ?
thiosulfate + cyanide thiocyanate is less toxic than cyanide Mycobacterium tuberculosis H37Rv sulfite + thiocyanate
-
 ?

Synonyms

Synonyms Comment Organism
CysA3
-
 Mycobacterium tuberculosis
MtbCysA3 rhodanese-like thiosulfate sulfurtransferase protein Mycobacterium tuberculosis