Literature summary for 2.8.1.1 extracted from

Billaut-Laden, I.; Allorge, D.; Crunelle-Thibaut, A.; Rat, E.; Cauffiez, C.; Chevalier, D.; Houdret, N.; Lo-Guidice, J.M.; Broly, F.
Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (rhodanese), a cyanide and H2S detoxification enzyme (2006), Toxicology, 225, 1-11.

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Protein Variants

Protein Variants	Comment	Organism
E102D	natural polymorphism, slight decrease both in Vmax and Km value	Homo sapiens
additional information	identification of eleven polymorphisms in 50 unrelated French individuals with Caucasian origin. Six polymorphisms lead to a significant decrease in promoter activity	Homo sapiens
P285A	natural polymorphism, ratio of Vmax to Km value is decreased by 50%	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.5	-	thiosulfate	mutant E102D, 30°C, pH 5.0	Homo sapiens
3.4	-	thiosulfate	wild-type, 30°C, pH 5.0	Homo sapiens
4.8	-	thiosulfate	mutant P285A, 30°C, pH 5.0	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	identification of functional genetic polymorphisms	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thiosulfate + cyanide	-	Homo sapiens	sulfite + thiocyanate	-	?

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Release 2023.1 (January 2023)