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Literature summary for 2.7.9.3 extracted from

  • Xu, X.M.; Carlson, B.A.; Irons, R.; Mix, H.; Zhong, N.; Gladyshev, V.N.; Hatfield, D.L.
    Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis (2007), Biochem. J., 404, 115-120.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis of SPS1 Mus musculus
DNA and amino acid sequence determination and analysis of SPS2, complementation of SPS2 knockout NIH3T3 cells by expression of SPS2 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knockdown of SPS1 has no effect. Transfection of SPS1 into SPS2-knockdown cells cannot restore selenoprotein biosynthesis/SPS2 function Mus musculus
additional information knockdown of SPS2 in NIH3T3 cells using small interfering RNA results in severely impaired selenoprotein biosynthesis. Transfection of SPS2 into SPS2-knockdown cells restores selenoprotein biosynthesis, but expression of SPS1 cannot complement SPS2 function Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus SPS1 probably has a specialized, non-essential role in selenoprotein metabolism ?
-
?
additional information Mus musculus SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus P97364
-
-
Mus musculus Q8BH69
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + selenide + H2O
-
Mus musculus AMP + selenophosphate + phosphate
-
?
additional information SPS1 probably has a specialized, non-essential role in selenoprotein metabolism Mus musculus ?
-
?
additional information SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
SelD
-
Mus musculus
selenophosphate synthetase
-
Mus musculus
selenophosphate synthetase 1
-
Mus musculus
selenophosphate synthetase 2
-
Mus musculus
SPS1
-
Mus musculus
Sps2
-
Mus musculus