Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis of SPS1 | Mus musculus |
DNA and amino acid sequence determination and analysis of SPS2, complementation of SPS2 knockout NIH3T3 cells by expression of SPS2 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of SPS1 has no effect. Transfection of SPS1 into SPS2-knockdown cells cannot restore selenoprotein biosynthesis/SPS2 function | Mus musculus |
additional information | knockdown of SPS2 in NIH3T3 cells using small interfering RNA results in severely impaired selenoprotein biosynthesis. Transfection of SPS2 into SPS2-knockdown cells restores selenoprotein biosynthesis, but expression of SPS1 cannot complement SPS2 function | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | SPS1 probably has a specialized, non-essential role in selenoprotein metabolism | ? | - |
? | |
additional information | Mus musculus | SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | P97364 | - |
- |
Mus musculus | Q8BH69 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NIH-3T3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + selenide + H2O | - |
Mus musculus | AMP + selenophosphate + phosphate | - |
? | |
additional information | SPS1 probably has a specialized, non-essential role in selenoprotein metabolism | Mus musculus | ? | - |
? | |
additional information | SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SelD | - |
Mus musculus |
selenophosphate synthetase | - |
Mus musculus |
selenophosphate synthetase 1 | - |
Mus musculus |
selenophosphate synthetase 2 | - |
Mus musculus |
SPS1 | - |
Mus musculus |
Sps2 | - |
Mus musculus |