Application | Comment | Organism |
---|---|---|
drug development | PPDK is not found in vertebrates, so specific inhibitors may be useful for treatment of infections caused by anaerobic protists that depend on pyrophosphate-dependent glycolysis | Giardia intestinalis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | application of ribozyme-mediated cleavage of the PPDK transcript to decrease PPDK transcript levels to 20% of normal level with an accompanying decrease in PPDK enzyme activity and decreased ATP levels to 3% of normal levels. Extracellular cleavage of PPDK mRNA by PPDK antisense RNA containing hammerhead ribozyme, overview | Giardia intestinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate + phosphate | Giardia intestinalis | PPDK catalyzes the generation of five ATP molecules from pyruvate by pyrophosphate-dependent glycolysis and offers a potential selective advantage | AMP + phosphoenolpyruvate + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Giardia intestinalis | Q27662 | from isolate C2 derived from a patient in Southwest China | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
trophozoite | - |
Giardia intestinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate + phosphate | - |
Giardia intestinalis | AMP + phosphoenolpyruvate + diphosphate | - |
? | |
ATP + pyruvate + phosphate | PPDK catalyzes the generation of five ATP molecules from pyruvate by pyrophosphate-dependent glycolysis and offers a potential selective advantage | Giardia intestinalis | AMP + phosphoenolpyruvate + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PPDK | - |
Giardia intestinalis |
pyrophosphate-dependent pyruvate phosphate dikinase | - |
Giardia intestinalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Giardia intestinalis |