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Literature summary for 2.7.9.1 extracted from

  • Feng, X.M.; Cao, L.J.; Adam, R.D.; Zhang, X.C.; Lu, S.Q.
    The catalyzing role of PPDK in Giardia lamblia (2008), Biochem. Biophys. Res. Commun., 367, 394-398.
    View publication on PubMed

Application

Application Comment Organism
drug development PPDK is not found in vertebrates, so specific inhibitors may be useful for treatment of infections caused by anaerobic protists that depend on pyrophosphate-dependent glycolysis Giardia intestinalis

Protein Variants

Protein Variants Comment Organism
additional information application of ribozyme-mediated cleavage of the PPDK transcript to decrease PPDK transcript levels to 20% of normal level with an accompanying decrease in PPDK enzyme activity and decreased ATP levels to 3% of normal levels. Extracellular cleavage of PPDK mRNA by PPDK antisense RNA containing hammerhead ribozyme, overview Giardia intestinalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate + phosphate Giardia intestinalis PPDK catalyzes the generation of five ATP molecules from pyruvate by pyrophosphate-dependent glycolysis and offers a potential selective advantage AMP + phosphoenolpyruvate + diphosphate
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?

Organism

Organism UniProt Comment Textmining
Giardia intestinalis Q27662 from isolate C2 derived from a patient in Southwest China
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Source Tissue

Source Tissue Comment Organism Textmining
trophozoite
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Giardia intestinalis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + phosphate
-
Giardia intestinalis AMP + phosphoenolpyruvate + diphosphate
-
?
ATP + pyruvate + phosphate PPDK catalyzes the generation of five ATP molecules from pyruvate by pyrophosphate-dependent glycolysis and offers a potential selective advantage Giardia intestinalis AMP + phosphoenolpyruvate + diphosphate
-
?

Synonyms

Synonyms Comment Organism
PPDK
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Giardia intestinalis
pyrophosphate-dependent pyruvate phosphate dikinase
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Giardia intestinalis

Cofactor

Cofactor Comment Organism Structure
ATP
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Giardia intestinalis