Protein Variants | Comment | Organism |
---|---|---|
D280A | partial activity | [Clostridium] symbiosum |
E279A | partial activity | [Clostridium] symbiosum |
R135A | partial activity, 15 mutant enzymes studied | [Clostridium] symbiosum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-adenylimidodiphosphate | - |
[Clostridium] symbiosum | |
adenosine | - |
[Clostridium] symbiosum | |
adenosine 5'-mono-O-phosphorothiolate | - |
[Clostridium] symbiosum | |
AMP | - |
[Clostridium] symbiosum | |
GMP | noncompetitive to ATP | [Clostridium] symbiosum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
AMP | pH 6.8, 25ºC, pyruvate-producing reaction, values for 7 mutant PPDK | [Clostridium] symbiosum | |
0.027 | - |
phosphoenolpyruvate | pH 6.8, 25ºC, pyruvate-producing reaction, values for 7 mutant PPDK | [Clostridium] symbiosum | |
0.081 | - |
ATP | pH 7, 25ºC, E279A mutant, phosphoenolpyruvate-producing reaction | [Clostridium] symbiosum | |
0.089 | - |
diphosphate | pH 6.8, 25ºC, pyruvate-producing reaction, values for 7 mutant PPDK | [Clostridium] symbiosum | |
0.1 | - |
2'-dAMP | pH 6.8, 25ºC | [Clostridium] symbiosum | |
0.19 | - |
ATP | pH 7, 25ºC, wild type and D280 mutant, phosphoenolpyruvate-producing reaction | [Clostridium] symbiosum | |
0.25 | - |
3'-dATP | pH 7, 25ºC | [Clostridium] symbiosum | |
0.28 | - |
2',3'-dideoxyadenosine 5'-triphosphate | pH 7, 25ºC | [Clostridium] symbiosum | |
0.35 | - |
2'-dATP | pH 7, 25ºC | [Clostridium] symbiosum | |
0.41 | - |
ATP | pH 7, 25ºC, R135A mutant, phosphoenolpyruvate-producing reaction | [Clostridium] symbiosum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
[Clostridium] symbiosum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2',3'-dideoxyadenosine 5'-triphosphate + pyruvate + phosphate | - |
[Clostridium] symbiosum | ? | - |
r | |
2'-dAMP + phosphoenolpyruvate + diphosphate | - |
[Clostridium] symbiosum | 2'-dATP + pyruvate + phosphate | - |
? | |
2'-dATP + pyruvate + phosphate | - |
[Clostridium] symbiosum | ? | - |
r | |
3'-dATP + pyruvate + phosphate | - |
[Clostridium] symbiosum | ? | - |
r |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
5'-adenylimidodiphosphate | pH 6.8, 25ºC | [Clostridium] symbiosum | |
0.31 | - |
adenosine 5'-mono-O-phosphorothiolate | pH 6.8, 25ºC | [Clostridium] symbiosum | |
0.32 | - |
adenosine | pH 6.8, 25ºC | [Clostridium] symbiosum | |
8.7 | - |
GMP | pH 6.8, 25ºC | [Clostridium] symbiosum |