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Literature summary for 2.7.8.B13 extracted from
- Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in bacteria and archaea, which contain inositol phospholipid (2013), Biochem. Biophys. Res. Commun., 443, 86-90.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Streptomyces avermitilis cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 76 pmol/h/mg and 20 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview | Streptomyces avermitilis |
| additional information | an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Propionibacterium acnes cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 88 pmol/h/mg and 14 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview | Cutibacterium acnes |
| additional information | an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Corynebacterium glutamicum cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 175 pmol/h/mg and 174 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview | Corynebacterium glutamicum |
| additional information | an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Rhodococcus equi cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 124 pmol/h/mg and 33 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview | Prescottella equi |
| additional information | an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Mycobacterium bovis cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 138 pmol/h/mg and 5 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview | Mycobacterium tuberculosis variant bovis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Corynebacterium glutamicum |  |
| Mg2+ | required | Cutibacterium acnes | |
| Mg2+ | required | Prescottella equi | |
| Mg2+ | required | Streptomyces avermitilis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | Streptomyces avermitilis | specificity of PIP synthase for lipid substrates | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | Cutibacterium acnes | specificity of PIP synthase for lipid substrates | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | Corynebacterium glutamicum | specificity of PIP synthase for lipid substrates | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | Prescottella equi | specificity of PIP synthase for lipid substrates | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | Mycobacterium tuberculosis variant bovis | specificity of PIP synthase for lipid substrates | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium glutamicum | - |
- |
- |
| Cutibacterium acnes | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mycobacterium tuberculosis variant bovis | - |
- |
- |
| Prescottella equi | - |
- |
- |
| Saccharolobus solfataricus | Q7LXU6 | - |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Streptomyces avermitilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-2,3-di-O-phytanyl-sn-glycerol + 1D-myo-inositol 1-phosphate | - |
Saccharolobus solfataricus | archaetidylinositol phosphate + CMP | - |
? | |
| CDP-2,3-di-O-phytanyl-sn-glycerol + 1D-myo-inositol 1-phosphate | - |
Saccharolobus solfataricus P2 | archaetidylinositol phosphate + CMP | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | specificity of PIP synthase for lipid substrates | Streptomyces avermitilis | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | specificity of PIP synthase for lipid substrates | Cutibacterium acnes | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | specificity of PIP synthase for lipid substrates | Corynebacterium glutamicum | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | specificity of PIP synthase for lipid substrates | Prescottella equi | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | specificity of PIP synthase for lipid substrates | Mycobacterium tuberculosis variant bovis | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | - |
Streptomyces avermitilis | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | - |
Cutibacterium acnes | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | - |
Corynebacterium glutamicum | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | - |
Prescottella equi | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-diacylglycerol + 1L-myo-inositol 1-phosphate | - |
Mycobacterium tuberculosis variant bovis | CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol phosphate synthase | - |
Streptomyces avermitilis |
| phosphatidylinositol phosphate synthase | - |
Cutibacterium acnes |
| phosphatidylinositol phosphate synthase | - |
Corynebacterium glutamicum |
| phosphatidylinositol phosphate synthase | - |
Prescottella equi |
| phosphatidylinositol phosphate synthase | - |
Mycobacterium tuberculosis variant bovis |
| PIP synthase | - |
Streptomyces avermitilis |
| PIP synthase | - |
Cutibacterium acnes |
| PIP synthase | - |
Corynebacterium glutamicum |
| PIP synthase | - |
Prescottella equi |
| PIP synthase | - |
Mycobacterium tuberculosis variant bovis |
| PIP synthase | - |
Homo sapiens |
| PIP synthase | - |
Saccharolobus solfataricus |
| PIP synthase | - |
Saccharomyces cerevisiae |
| PIPS | - |
Homo sapiens |
| PIPS | - |
Saccharolobus solfataricus |
| PIPS | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Corynebacterium glutamicum |
| 37 | - |
assay at | Cutibacterium acnes |
| 37 | - |
assay at | Prescottella equi |
| 37 | - |
assay at | Streptomyces avermitilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Streptomyces avermitilis |
| 8 | - |
assay at | Cutibacterium acnes |
| 8 | - |
assay at | Corynebacterium glutamicum |
| 8 | - |
assay at | Prescottella equi |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | required | Homo sapiens | |
| NAD+ | required | Saccharolobus solfataricus | |
| NAD+ | required | Saccharomyces cerevisiae | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid | Streptomyces avermitilis |
| metabolism | in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid | Cutibacterium acnes |
| metabolism | in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid | Corynebacterium glutamicum |
| metabolism | in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid | Prescottella equi |
| metabolism | in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid | Mycobacterium tuberculosis variant bovis |
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