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Literature summary for 2.7.8.B10 extracted from

  • Rossi, R.; Yum, L.; Agaisse, H.; Payne, S.
    Cardiolipin synthesis and outer membrane localization are required for Shigella flexneri virulence (2017), mBio, 8, e01199 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Shigella flexneri Q83RM8
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
clsA
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Shigella flexneri

General Information

General Information Comment Organism
physiological function a ClsA mutant has no cardiolipin detected within its membrane, grows normally in vitro, and invades cultured epithelial cells, but it fails to form plaques in epithelial cell monolayers. The ClsA mutant is initially motile within the host cell cytoplasm but forms filaments and loses motility during replication and fails to spread efficiently to neighboring cells Shigella flexneri