Protein Variants | Comment | Organism |
---|---|---|
H113A | mutation in HKD motif, catalyticlly inactive | Escherichia coli |
H291A | mutation in HKD motif, catalyticlly inactive | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0AA84 | i.e. ClsB | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a phosphatidylglycerol + a phosphatidylglycerol | - |
Escherichia coli | cardiolipin + glycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
clsB | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | ClsB additionally catalyzes an alternative mechanism for phosphatidylglycerol synthesis that is PgsA-independent. The reaction in vivo and in vitro converts phosphatidylethanolamine and glycerol into phosphatidylglycerol. When the growth medium is supplemented with glycerol, the expression ClsB significantly increases phosphatidylglycerol and cardiolipin levels, with the growth deficiency of PgsA null strain also being complemented under such conditions | Escherichia coli |