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Literature summary for 2.7.8.B10 extracted from

  • Li, C.; Tan, B.K.; Zhao, J.; Guan, Z.
    In vivo and in vitro synthesis of phosphatidylglycerol by an Escherichia coli cardiolipin synthase (2016), J. Biol. Chem., 291, 25144-25153 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H113A mutation in HKD motif, catalyticlly inactive Escherichia coli
H291A mutation in HKD motif, catalyticlly inactive Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AA84 i.e. ClsB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a phosphatidylglycerol + a phosphatidylglycerol
-
Escherichia coli cardiolipin + glycerol
-
?

Synonyms

Synonyms Comment Organism
clsB
-
Escherichia coli

General Information

General Information Comment Organism
physiological function ClsB additionally catalyzes an alternative mechanism for phosphatidylglycerol synthesis that is PgsA-independent. The reaction in vivo and in vitro converts phosphatidylethanolamine and glycerol into phosphatidylglycerol. When the growth medium is supplemented with glycerol, the expression ClsB significantly increases phosphatidylglycerol and cardiolipin levels, with the growth deficiency of PgsA null strain also being complemented under such conditions Escherichia coli