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Literature summary for 2.7.8.B10 extracted from
- Complex evolution of two types of cardiolipin synthase in the eukaryotic lineage stramenopiles (2016), Mol. Phylogenet. Evol., 101, 133-141.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CLS_pld, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview | Wobblia lunata |
| CLS_pld, phylogenetic analysis, overview | Cafeteria sp. |
| CLS_pld, phylogenetic analysis, overview | Cantina marsupialis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | in mitochondrion-related organelles (degenerated mitochondria) | Cantina marsupialis | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a phosphatidylglycerol + a phosphatidylglycerol | Wobblia lunata | - |
a cardiolipin + glycerol | - |
? |  |
| a phosphatidylglycerol + a phosphatidylglycerol | Cafeteria sp. | - |
a cardiolipin + glycerol | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | Cantina marsupialis | - |
a cardiolipin + glycerol | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | Wobblia lunata NIES1015 | - |
a cardiolipin + glycerol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cafeteria sp. | - |
Caron, lab isolate | - |
| Cantina marsupialis | - |
a free-living anaerobic stramenopile | - |
| no activity in Cafeteria roenbergensis | - |
strain NIES1012 | - |
| no activity in Developayella elegans | - |
strain NIES1388 | - |
| Wobblia lunata | - |
- |
- |
| Wobblia lunata NIES1015 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Wobblia lunata | a cardiolipin + glycerol | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Cafeteria sp. | a cardiolipin + glycerol | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Cantina marsupialis | a cardiolipin + glycerol | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Wobblia lunata NIES1015 | a cardiolipin + glycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cardiolipin synthase | - |
Wobblia lunata |
| cardiolipin synthase | - |
Cafeteria sp. |
| cardiolipin synthase | - |
Cantina marsupialis |
| CL synthase | - |
Wobblia lunata |
| CL synthase | - |
Cafeteria sp. |
| CL synthase | - |
Cantina marsupialis |
| CLS_pld | - |
Wobblia lunata |
| CLS_pld | - |
Cafeteria sp. |
| CLS_pld | - |
Cantina marsupialis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cafeteria sp. Caron contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue | Cafeteria sp. |
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cantina marsupialis contains only a CLS_pld enzyme homologue, no CLS_cap, EC 2.7.8.41, homologue | Cantina marsupialis |
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Wobblia lunata contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue | Wobblia lunata |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates | Wobblia lunata |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates | Cafeteria sp. |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates | Cantina marsupialis |
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