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Literature summary for 2.7.8.B10 extracted from
- Alternative cardiolipin synthase Cls1 compensates for stalled Cls2 function in Staphylococcus aureus under conditions of acute acid stress (2013), FEMS Microbiol. Lett., 338, 141-146.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme Cls1 can induce CL production in response to broad high osmolality stressors, such as 4 M NaCl, 4 M KCl or 20% raffinose in the cls2 mutant (Ncls2), although not in the wild-type | Staphylococcus aureus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene cls1, phylogenetic analysis | Staphylococcus aureus |
| gene cls2, cls2 encodes a housekeeping-type CL synthase, phylogenetic analysis | Staphylococcus aureus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a phosphatidylglycerol + a phosphatidylglycerol | Staphylococcus aureus | - |
a cardiolipin + glycerol | - |
? |  |
| a phosphatidylglycerol + a phosphatidylglycerol | Staphylococcus aureus N315 | - |
a cardiolipin + glycerol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | A0A0H3JKV8 | - |
- |
| Staphylococcus aureus | P63801 | - |
- |
| Staphylococcus aureus N315 | A0A0H3JKV8 | - |
- |
| Staphylococcus aureus N315 | P63801 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Staphylococcus aureus | a cardiolipin + glycerol | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Staphylococcus aureus N315 | a cardiolipin + glycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cardiolipin synthase | - |
Staphylococcus aureus |
| CL synthase | - |
Staphylococcus aureus |
| CLS1 | - |
Staphylococcus aureus |
| cls2 | - |
Staphylococcus aureus |
| SA1155 | - |
Staphylococcus aureus |
| SA1891 | - |
Staphylococcus aureus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | phylogenetic analysis reveals that gene cls1 is generated through the duplication of gene cls2 after the divergence of the genus Staphylococcus | Staphylococcus aureus |
| malfunction | a cls1 mutant is equal to the wild-type in terms of CL accumulation and stress tolerance. But below pH 2.6, the cls1 mutant (i.e. carrying Cls2 alone) cannot produce cardiolipin | Staphylococcus aureus |
| malfunction | a cls2 mutant (carrying Cls1 alone) effectively accumulates cardiolipin at pH 2.6 and below | Staphylococcus aureus |
| physiological function | alternative cardiolipin synthase Cls1 compensates for stalled Cls2 function in Staphylococcus aureus under conditions of acute acid stress. Gene cls2 encodes a housekeeping-type CL synthase | Staphylococcus aureus |
| physiological function | alternative cardiolipin synthase Cls1 compensates for stalled Cls2 function in Staphylococcus aureus under conditions of acute acid stress. The physiological role of cls1 is to synthesize cardiolipin under conditions of acute low-pH stress | Staphylococcus aureus |
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