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Literature summary for 2.7.8.7 extracted from

  • Nair, D.R.; Ghosh, R.; Manocha, A.; Mohanty, D.; Saran, S.; Gokhale, R.S.
    Two functionally distinctive phosphopantetheinyl transferases from amoeba Dictyostelium discoideum (2011), PLoS ONE, 6, e24262.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Dictyostelium discoideum 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
x * 20000, isoform AcpS, calculated from amino acid sequence Dictyostelium discoideum
27000
-
x * 27000, isoform AcpS, SDS-PAGE Dictyostelium discoideum
34000
-
x * 34000, isoform Sfp, calculated from amino acid sequence Dictyostelium discoideum
34000
-
x * 34000, isoform Sfp, SDS-PAGE Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum Q54MI2 isoform Sfp
-
Dictyostelium discoideum Q552R4 isoform AcpS
-
Dictyostelium discoideum AX2 Q54MI2 isoform Sfp
-
Dictyostelium discoideum AX2 Q552R4 isoform AcpS
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + acyl-carrier protein substrate for isoform AcpS Dictyostelium discoideum CoA + acetyl-[acyl-carrier protein]
-
?
acetyl-CoA + acyl-carrier protein substrate for isoform AcpS Dictyostelium discoideum AX2 CoA + acetyl-[acyl-carrier protein]
-
?
acetyl-CoA + polyketide synthase 1 substrate for isoform Sfp Dictyostelium discoideum CoA + acetyl-polyketide synthase 1
-
?
acetyl-CoA + polyketide synthase 1 substrate for isoform Sfp Dictyostelium discoideum AX2 CoA + acetyl-polyketide synthase 1
-
?
acetyl-CoA + polyketide synthase 16 substrate for isoform Sfp Dictyostelium discoideum CoA + acetyl-polyketide synthase 16
-
?
acetyl-CoA + polyketide synthase 16 substrate for isoform Sfp Dictyostelium discoideum AX2 CoA + acetyl-polyketide synthase 16
-
?
acetyl-CoA + polyketide synthase 2 substrate for isoform Sfp Dictyostelium discoideum CoA + acetyl-polyketide synthase 2
-
?
acetyl-CoA + polyketide synthase 2 substrate for isoform Sfp Dictyostelium discoideum AX2 CoA + acetyl-polyketide synthase 2
-
?
additional information isoform AcpS shows weak activity with mycobacterial polyketide synthase 2 Dictyostelium discoideum ?
-
?
additional information isoform Sfp exhibits weak activity with acetyl-CoA Dictyostelium discoideum ?
-
?
additional information isoform Sfp exhibits weak activity with acetyl-CoA Dictyostelium discoideum AX2 ?
-
?
additional information isoform AcpS shows weak activity with mycobacterial polyketide synthase 2 Dictyostelium discoideum AX2 ?
-
?

Subunits

Subunits Comment Organism
? x * 20000, isoform AcpS, calculated from amino acid sequence Dictyostelium discoideum
? x * 27000, isoform AcpS, SDS-PAGE Dictyostelium discoideum
? x * 34000, isoform Sfp, calculated from amino acid sequence Dictyostelium discoideum
? x * 34000, isoform Sfp, SDS-PAGE Dictyostelium discoideum

Synonyms

Synonyms Comment Organism
AcpS isoform Dictyostelium discoideum
phosphopantetheinyl transferase
-
Dictyostelium discoideum
PPTase
-
Dictyostelium discoideum
Sfp isoform Dictyostelium discoideum

General Information

General Information Comment Organism
metabolism isoform AcpS specifically modifies a stand-alone acyl carrier protein that possesses a mitochondrial import signal Dictyostelium discoideum
metabolism isoform Sfp in contrast is specific to type I multifunctional polyketide synthase/fatty acid synthase proteins and cannot modify the stand-alone acyl carrier protein Dictyostelium discoideum