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Literature summary for 2.7.8.7 extracted from

  • Strickland, K.C.; Hoeferlin, L.A.; Oleinik, N.V.; Krupenko, N.I.; Krupenko, S.A.
    Acyl carrier protein-specific 4-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase (2010), J. Biol. Chem., 285, 1627-1633.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.7

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)-codon plus cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000, recombinant His-tagged enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA-[4'-phosphopantetheine] + apo-[FDH protein] the enzyme modifies the apo-FDH protein at serine 354 and activates its catalysis Homo sapiens adenosine 3',5'-bisphosphate + holo-[FDH protein]
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, recombinant His-tagged enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
acyl carrier protein-specific 4'-phosphopantetheinyl transferase
-
 Homo sapiens
PPT
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme silencing by small interfering RNA in A-549 cells prevents FDH modification. Enzyme-silenced cells demonstrate significantly reduced proliferation and undergo strong G1 arrest Homo sapiens