Literature summary for 2.7.8.7 extracted from

Gilbert, A.M.; Kirisits, M.; Toy, P.; Nunn, D.S.; Failli, A.; Dushin, E.G.; Novikova, E.; Petersen, P.J.; Joseph-McCarthy, D.; McFadyen, I.; Fritz, C.C.
Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors (2004), Bioorg. Med. Chem. Lett., 14, 37-41.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-5-fluoro-benzoic acid	IC50: 0.0021 mM	Bacillus subtilis
2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.015 mM	Bacillus subtilis
5-bromo-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.0015 mM	Bacillus subtilis
5-bromo-2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.0034 mM	Bacillus subtilis
5-bromo-4-chloro-2-[[5-oxo-2-(4-trifluoromethyl-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.002 mM	Bacillus subtilis
5-carboxyamino-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.00013 mM	Bacillus subtilis
5-chloro-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.0011 mM	Bacillus subtilis
5-fluoro-2-[[5-oxo-2-(4-trifluoromethyl-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.0019 mM	Bacillus subtilis
5-iodo-2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.0013 mM	Bacillus subtilis
5-methyl-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.00027 mM	Bacillus subtilis
5-methyl-2-[[5-oxo-2-(3-trifluoromethoxy-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.0044 mM	Bacillus subtilis
5-methyl-2-[[5-oxo-2-(4-trifluoromethyl-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid	IC50: 0.00083 mM	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-

Synonyms

Synonyms	Comment	Organism
AcpS	-	Bacillus subtilis
acyl carrier protein synthase	-	Bacillus subtilis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00013	-	IC50: 0.00013 mM	Bacillus subtilis	5-carboxyamino-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.00027	-	IC50: 0.00027 mM	Bacillus subtilis	5-methyl-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.00083	-	IC50: 0.00083 mM	Bacillus subtilis	5-methyl-2-[[5-oxo-2-(4-trifluoromethyl-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.0011	-	IC50: 0.0011 mM	Bacillus subtilis	5-chloro-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.0013	-	IC50: 0.0013 mM	Bacillus subtilis	5-iodo-2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.0015	-	IC50: 0.0015 mM	Bacillus subtilis	5-bromo-2-[[2-(3-fluoro-4-trifluoromethyl-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.0019	-	IC50: 0.0019 mM	Bacillus subtilis	5-fluoro-2-[[5-oxo-2-(4-trifluoromethyl-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.002	-	IC50: 0.002 mM	Bacillus subtilis	5-bromo-4-chloro-2-[[5-oxo-2-(4-trifluoromethyl-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.0021	-	IC50: 0.0021 mM	Bacillus subtilis	2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-5-fluoro-benzoic acid
0.0034	-	IC50: 0.0034 mM	Bacillus subtilis	5-bromo-2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.0044	-	IC50: 0.0044 mM	Bacillus subtilis	5-methyl-2-[[5-oxo-2-(3-trifluoromethoxy-phenyl)-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid
0.015	-	IC50: 0.015 mM	Bacillus subtilis	2-[[2-(4-chloro-phenyl)-5-oxo-oxazolidin-(4E)-ylidenemethyl]-amino]-benzoic acid

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Release 2023.1 (January 2023)