Literature summary for 2.7.8.5 extracted from

He, Q.; Greenberg, M.L.
Post-translational regulation of phosphatidylglycerolphosphate synthase in response to inositol (2004), Mol. Microbiol., 53, 1243-1249.

Search for more literature for 2.7.8.5

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate	Saccharomyces cerevisiae	the enzyme catalyzes the first committed step in synthesis of cardiolipid. In response to inositol, decrease in Pgs1p enzyme activity is associated with increased phosphorylation of Pgs1p. Phosphorylation of a phospholipid biosynthetic enzyme in response to inositol, new mechanism of inositol-mediated regulation	CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	in response to inositol, decrease in Pgs1p enzyme activity is associated with increased phosphorylation of Pgs1p. Phosphorylation of a phospholipid biosynthetic enzyme in response to inositol, new mechanism of inositol-mediated regulation	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate	the enzyme catalyzes the first committed step in synthesis of cardiolipid. In response to inositol, decrease in Pgs1p enzyme activity is associated with increased phosphorylation of Pgs1p. Phosphorylation of a phospholipid biosynthetic enzyme in response to inositol, new mechanism of inositol-mediated regulation	Saccharomyces cerevisiae	CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Pgs1p	-	Saccharomyces cerevisiae
phosphatidylglycerolphosphate synthase	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)