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Literature summary for 2.7.8.45 extracted from

  • Brown, S.; Meredith, T.; Swoboda, J.; Walker, S.
    Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways (2010), Chem. Biol., 17, 1101-1110.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q2G1C1
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Staphylococcus aureus NCTC 8325 Q2G1C1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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 Staphylococcus aureus CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol transfer of a single glycerol-phosphate unit. Under high enzyme and substrate concentrations for prolonged reaction times, an additional product containing three glycerol-phosphate units can also be observed ?
CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
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 Staphylococcus aureus NCTC 8325 CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol transfer of a single glycerol-phosphate unit. Under high enzyme and substrate concentrations for prolonged reaction times, an additional product containing three glycerol-phosphate units can also be observed ?

General Information

General Information Comment Organism
physiological function Staphylococcus aureus requires a glycerol-phosphate primase called TarF in order make polyribitol-phosphate-wall teichoic acids. TarF is essentisal in wild-type background but can be deleted in a strain expression Bacillus subtilis TarK-TarL Staphylococcus aureus