Literature summary for 2.7.8.45 extracted from

  • Brown, S.; Zhang, Y.; Walker, S.
    a revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps (2008), Chem. Biol., 15, 12-21.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q2G1C1
-
-
Staphylococcus aureus NCTC 8325 Q2G1C1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
Staphylococcus aureus CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol enzyme TarF adds one unit of glycerol-3-phosphate to 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol to produce (glycerol-3-phosphate)2-ManNAc-beta-(1,4)-GlcNAc-diphospho-lipid ?
CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
Staphylococcus aureus NCTC 8325 CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol enzyme TarF adds one unit of glycerol-3-phosphate to 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol to produce (glycerol-3-phosphate)2-ManNAc-beta-(1,4)-GlcNAc-diphospho-lipid ?

Synonyms

Synonyms Comment Organism
tarF
-
Staphylococcus aureus
SAOUHSC_00223
-
Staphylococcus aureus

General Information

General Information Comment Organism
physiological function gene products TarA, TarB, TarF, and TarL are required to convert the GlcNAc-diphosphate-lipid product of TarO to the full-length polyribitol polymer Staphylococcus aureus