Literature summary for 2.7.8.41 extracted from

Tu, C.; Xiong, H.; Hu, Y.; Wang, W.; Mei, G.; Wang, H.; Li, Y.; Zhou, Z.; Meng, F.; Zhang, P.; Mei, Z.
Cardiolipin synthase 1 ameliorates NASH through activating transcription factor 3 transcriptional inactivation (2020), Hepatology, 72, 1949-1967 .

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Application

Application	Comment	Organism
medicine	CRLS1 expression is significantly downregulated in genetically obese and diet-induced mice models	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q80ZM8	-	-

Synonyms

Synonyms	Comment	Organism
Crls1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	overexpression of Crls1 markedly attenuates hepatic steatosis and inflammation in hepatocytes, whereas shRNA-mediated Crls1 knockdown aggravates these abnormalities. High-fat diet-induced insulin resistance and hepatic steatosis are significantly exacerbated in hepatocyte-specific Crls1-knockout mice. Crls1 depletion significantly aggravates high-fat and high-cholesterol diet-induced inflammatory response and fibrosis during nonalcoholic hepatic steatosis development. Crls1 deficiency leads to a prominently aggravated lipid metabolism disorder. Activating transcription factor 3 (ATF3) is the key differentially expressed gene in Crls1-knockout mice	Mus musculus

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Release 2023.1 (January 2023)