Literature summary for 2.7.8.41 extracted from

Matsumura, A.; Higuchi, J.; Watanabe, Y.; Kato, M.; Aoki, K.; Akabane, S.; Endo, T.; Oka, T.
Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology (2018), FEBS Lett., 592, 209-218 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-
mitochondrion	-	Caenorhabditis elegans	5739	-

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	O01916	-	-
Homo sapiens	Q9UJA2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Crls1	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	knockdown of cardiolipin synthase induces mitochondrial elongation in body wall muscle cells. Knockdown of other genes involved in cardiolipin synthesis does not influence mitochondrial morphology. Knocking down cardiolipin synthase decreases mitochondrial division	Caenorhabditis elegans
physiological function	knockdown of cardiolipin synthase induces mitochondrial elongation in human cells. In cardiolipin synthase-knocked down cells a decreased amount of cardiolipin and an accumulation of phosphatidylglycerol is observed. Knockdown of other genes involved in cardiolipin synthesis does not influence mitochondrial morphology	Homo sapiens

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Release 2023.1 (January 2023)