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Literature summary for 2.7.8.41 extracted from

  • Sustarsic, E.; Ma, T.; Lynes, M.; Larsen, M.; Karavaeva, I.; Havelund, J.; Nielsen, C.; Jedrychowski, M.; Moreno-Torres, M.; Lundh, M.; Plucinska, K.; Jespersen, N.; Grevengoed, T.; Kramar, B.; Peics, J.; Hansen, J.; Shamsi, F.; Forss, I.; Neess, D.
    Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis (2018), Cell Metab., 28, 159-174.e11 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine expression of Crls1 mRNA is significantly reduced in subcutaneous fat from diabetic subjects. The Crls1 mRNA levels in human subcutaneous white adipose tissue negatively correlate with HOMA2 measures of insulin resistance and positively correlate with HOMA2 measures of insulin sensitivity. Increased CRLS1 expression in human white adipocytes stimulates UCP1 expression and increases inducible uncoupled respiration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UJA2
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-
Mus musculus Q80ZM8
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-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
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 Mus musculus
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brown adipose tissue
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 Homo sapiens
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white adipose tissue
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 Mus musculus
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white adipose tissue
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Crls1
-
 Mus musculus
Crls1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function synthesis of cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Overexpression of cardiolipin synthase Crls1 enhances energy consumption in adipocytes, and adipose Crls1 levels positively correlate with insulin sensitivity Homo sapiens
physiological function synthesis of cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Overexpression of cardiolipin synthase Crls1 enhances energy consumption in adipocytes. Crls1 deficiency in thermogenic adipocytes diminishes inducible mitochondrial uncoupling and elicits a nuclear transcriptional response through endoplasmic reticulum stress-mediated retrograde communication. Cardiolipin depletion in brown and beige fat abolishes adipose thermogenesis and glucose uptake, which renders animals insulin resistant Mus musculus