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Literature summary for 2.7.8.41 extracted from

  • Nowicki, M.; Müller, F.; Frentzen, M.
    Cardiolipin synthase of Arabidopsis thaliana (2005), FEBS Lett., 579, 2161-2165.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
Triton X-100 0.2 mM, 50% inhibition. Concentrations higher than 0.6 mM result in an almost complete inhibition Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
CDP-dioleoylglycerol pH 8.8, 30°C Arabidopsis thaliana
0.15
-
dioleoylphosphatidylglycerol pH 8.8, 30°C Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Arabidopsis thaliana 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
CoCl2 requires divalent cations for activity. Highest activities are measured in the presence of 20 mM MnCl2, while MgCl2 or CoCl2 stimulate the activity only slightly Arabidopsis thaliana
MgCl2 requires divalent cations for activity. Highest activities are measured in the presence of 20 mM MnCl2, while MgCl2 or CoCl2 stimulate the activity only slightly Arabidopsis thaliana
MnCl2 requires divalent cations for activity. Highest activities are measured in the presence of 20 mM MnCl2, while MgCl2 or CoCl2 stimulate the activity only slightly Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q93YW7
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the preprotein expressed in yeast can be imported into mitochondria and processed to a catalytically active protein Arabidopsis thaliana

Purification (Commentary)

Purification (Comment) Organism
-
Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-dioleoylglycerol + dioleoylphosphatidylglycerol the enzyme is less active with phosphatidyl-glycerol species carrying one or two palmitoyl groups than with the dioleoyl species of phosphatidyl-glycerol. In addition, CDP-dipalmitoylglycerol hardly competes with CDP-dioleolyglycerol as substrate Arabidopsis thaliana a cardiolipin + CMP
-
?
CDP-dioleoylglycerol + dipalmitoylphosphatidylglycerol the enzyme is less active with phosphatidyl-glycerol species carrying one or two palmitoyl groups than with the dioleoyl species of phosphatidyl-glycerol. In addition, CDP-dipalmitoylglycerol hardly competes with CDP-dioleolyglycerol as substrate Arabidopsis thaliana a cardiolipin + CMP
-
?

Synonyms

Synonyms Comment Organism
At4g04870
-
Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8
-
assay at Arabidopsis thaliana
9
-
-
Arabidopsis thaliana