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Literature summary for 2.7.8.41 extracted from
- Biochemical characterization and regulation of cardiolipin synthase in Saccharomyces cerevisiae (1990), Biochim. Biophys. Acta, 1046, 214-222.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton | maximal activity is obtained with a Triton X-100:phospholipid ratio of 1:1 | Saccharomyces cerevisiae |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2-dioleoylphosphatidylglycerol | above 0.65 mM | Saccharomyces cerevisiae | |
| CDP-dioleoylglycerol | above 0.1 mM | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.036 | - |
CDP-dioleoylglycerol | pH 9.0, 45°C | Saccharomyces cerevisiae | |
| 1 | - |
1,2-dioleoylphosphatidylglycerol | pH 9.0, 45°C | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | maximal activity is obtained in the presence of 20 mM Mg2+ | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | Q07560 | - |
- |
| Saccharomyces cerevisiae ATCC 204508 | Q07560 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-dioleoylglycerol + 1,2-dioleoylphosphatidylglycerol | - |
Saccharomyces cerevisiae | 1,3-bis(1,2-dioleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP | - |
? | |
| CDP-dioleoylglycerol + 1,2-dioleoylphosphatidylglycerol | - |
Saccharomyces cerevisiae ATCC 204508 | 1,3-bis(1,2-dioleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CLS1 | - |
Saccharomyces cerevisiae |
| CRD1 | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Saccharomyces cerevisiae |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | 65 | 35°C: about 45% of maximal activity, 65°C: about 40% of maximal activity | Saccharomyces cerevisiae |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
20 min, stable up to | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Saccharomyces cerevisiae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 10 | pH 7.5: about 45% of maximal activity, pH 10.0: about 85% of maximal activity | Saccharomyces cerevisiae |
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