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Literature summary for 2.7.8.39 extracted from
- A novel biosynthetic pathway of archaetidyl-myo-inositol via archaetidyl-myo-inositol phosphate from CDP-archaeol and D-glucose 6-phosphate in methanoarchaeon Methanothermobacter thermautotrophicus cells (2009), J. Biol. Chem., 284, 30766-30774.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | 0.5%, stimulates | Methanothermobacter thermautotrophicus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Methanothermobacter thermautotrophicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Pyrococcus furiosus | 16020 | - |
| membrane | - |
Methanothermobacter thermautotrophicus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | Mg2+ or Mn2+ required | Methanothermobacter thermautotrophicus | |
| Mn2+ | Mg2+ or Mn2+ required | Methanothermobacter thermautotrophicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20764 | - |
x * 20764, calculated from sequence | Methanothermobacter thermautotrophicus |
| 20900 | - |
x * 20900, SDS-PAGE | Methanothermobacter thermautotrophicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-2,3-bis-O-(phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate | Methanothermobacter thermautotrophicus | the enzyme is involved in biosynthesis of archaetidyl-myo-inositol | CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanothermobacter thermautotrophicus | O27726 | - |
- |
| Pyrococcus furiosus | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.02 | - |
pH 8.0, 60°C, crude enzyme | Methanothermobacter thermautotrophicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-2,3-bis-O-(phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate | - |
Methanothermobacter thermautotrophicus | CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate | - |
? | |
| CDP-2,3-bis-O-(phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate | the enzyme is involved in biosynthesis of archaetidyl-myo-inositol | Methanothermobacter thermautotrophicus | CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 20900, SDS-PAGE | Methanothermobacter thermautotrophicus |
| ? | x * 20764, calculated from sequence | Methanothermobacter thermautotrophicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AIP synthase | - |
Methanothermobacter thermautotrophicus |
| MTH1691 | - |
Methanothermobacter thermautotrophicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
assay at | Methanothermobacter thermautotrophicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Methanothermobacter thermautotrophicus |
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