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Literature summary for 2.7.8.35 extracted from
- Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG 4947 have WecA function and MSMEG 4947 is required for the growth of M. smegmatis (2010), FEMS Microbiol. Lett., 310, 54-61.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in wecA-defective Escherichia coli MV501 cells | Mycolicibacterium smegmatis |
| expressed in wecA-defective Escherichia coli MV501 cells | Mycobacterium tuberculosis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycolicibacterium smegmatis | - |
- |
- |
| Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-alpha-D-glucosamine + trans,octacis-decaprenyl phosphate | - |
Mycolicibacterium smegmatis | UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | - |
r |  |
| UDP-N-acetyl-alpha-D-glucosamine + trans,octacis-decaprenyl phosphate | - |
Mycobacterium tuberculosis | UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | - |
r | |
| UDP-N-acetyl-alpha-D-glucosamine + trans,octacis-decaprenyl phosphate | - |
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MSMEG 4947 | - |
Mycolicibacterium smegmatis |
| Rv1302 | - |
Mycobacterium tuberculosis |
| UDP-GlcNAc: undecaprenyl phosphate GlcNAc-1-phosphate transferase | - |
Mycolicibacterium smegmatis |
| UDP-GlcNAc: undecaprenyl phosphate GlcNAc-1-phosphate transferase | - |
Mycobacterium tuberculosis |
| WecA | - |
Mycolicibacterium smegmatis |
| WecA | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the disruption of MSMEG 4947 in the Mycobaterium smegmatis genome results in the loss of viability at 42°C and causes drastic morphological changes like pear shape and larger diameter | Mycolicibacterium smegmatis |
| metabolism | the enzyme catalyzes the first step in the biosynthesis of lipopolysaccharide O-antigen | Mycolicibacterium smegmatis |
| metabolism | the enzyme catalyzes the first step in the biosynthesis of lipopolysaccharide O-antigen | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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