Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.24 extracted from

  • Palusinska-Szysz, M.; Szuster-Ciesielska, A.; Kania, M.; Janczarek, M.; Chmiel, E.; Danikiewicz, W.
    Legionella dumoffii utilizes exogenous choline for phosphatidylcholine synthesis (2014), Int. J. Mol. Sci., 15, 8256-8279.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.24

Application

Application Comment Organism
analysis since choline is not a biosynthetic product of prokaryotes, the Pcs pathway is probably a direct sensor of environmental conditions, using choline availability as an indicator of the status of the location in which the bacterium is found Fluoribacter dumoffii
additional information since choline is not a biosynthetic product of prokaryotes, the Pcs pathway is probably a direct sensor of environmental conditions, using choline availability as an indicator of the status of the location in which the bacterium is found Fluoribacter dumoffii

Cloned(Commentary)

Cloned (Comment) Organism
gene pcsA, DNA and amino acid sequence determination and analysis Fluoribacter dumoffii

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane localization of phosphatidylcholine in the outer and inner membranes by LC/ESI-MS analysis Fluoribacter dumoffii 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + choline Fluoribacter dumoffii the enzyme utilizes exogenous choline for phosphatidylcholine synthesis CMP + phosphatidylcholine
-
 r

Organism

Organism UniProt Comment Textmining
Fluoribacter dumoffii S4X5L9 gene pcsA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + choline
-
 Fluoribacter dumoffii CMP + phosphatidylcholine
-
 r
CDP-diacylglycerol + choline the enzyme utilizes exogenous choline for phosphatidylcholine synthesis Fluoribacter dumoffii CMP + phosphatidylcholine
-
 r

Synonyms

Synonyms Comment Organism
PcsA
-
 Fluoribacter dumoffii

General Information

General Information Comment Organism
metabolism the phosphatidylcholine synthase pathway is the primary pathway for synthesis of phosphatidylcholine in Legionelly dumoffii. Choline is condensed directly with CDP-diacylglyceride to form phosphatidylcholine in a reaction catalyzed by a bacterium-specific Pcs enzyme Fluoribacter dumoffii
physiological function the enzyme synthesizes phosphatidylcholine, a membrane-forming phospholipid, via the phosphatidylcholine synthase pathway, Pcs. Structurally different PC species are distributed in the outer and inner membranes Fluoribacter dumoffii