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Literature summary for 2.7.8.24 extracted from

  • Conover, G.M.; Martinez-Morales, F.; Heidtman, M.I.; Luo, Z.Q.; Tang, M.; Chen, C.; Geiger, O.; Isberg, R.R.
    Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants (2008), Cell. Microbiol., 10, 514-528.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
from plasmid pGC41 in pGC36 for functional complementation in bacterial mutants lacking endogenous PcsA Legionella pneumophila

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + choline Legionella pneumophila phosphatidylcholine synthesis important for functionality of Dot/Icm translocator (formation of replicative vacuole), binding to macrophages, sufficient level of flagellin protein (linked to bacterial cytotoxicity, cellular adhesion) CMP + phosphatidylcholine
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?

Organism

Organism UniProt Comment Textmining
Legionella pneumophila
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Philadelphia-1 strain Lp02 derivatives
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + choline phosphatidylcholine synthesis important for functionality of Dot/Icm translocator (formation of replicative vacuole), binding to macrophages, sufficient level of flagellin protein (linked to bacterial cytotoxicity, cellular adhesion) Legionella pneumophila CMP + phosphatidylcholine
-
?
CDP-diacylglycerol + choline overexpression of PcsA complements low phosphatidylcholine levels in membrane of mutant strain lacking PcsA or lacking both PcsA and PmtA (phospholipid N-methyltransferase) Legionella pneumophila CMP + phosphatidylcholine lipid analysis by thin-layer chromatography ?

Synonyms

Synonyms Comment Organism
PcsA
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Legionella pneumophila
PcsA lidK/pcsA gene product Legionella pneumophila
phosphatidylcholine synthase
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Legionella pneumophila