Literature summary for 2.7.8.23 extracted from

Hidaka, T.; Hara, O.; Imai, S.; Anzai, H.; Murakami, T.; Nakaoka, K.; Seto, H.
Biochemical mechanism of C-P bond formation of bialaphos: use of gene manipulation for the analysis of the C-P bond formation step (1990), Agric. Biol. Chem., 54, 2121-2125.

Search for more literature for 2.7.8.23

Application

Application	Comment	Organism
agriculture	formation of one of the two C-P bonds in the tripeptide antibiotic bialaphos, a potent herbicide isolated from Streptomyces hygroscopicus SF1293, enzyme is produced in large amounts by high producer strain HP5-29, enzyme may contribute to improvement of bialphos production	Streptomyces hygroscopicus

Cloned(Commentary)

Cloned (Comment)	Organism
mutant NP71 constructed by gene replacement technique	Streptomyces hygroscopicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
carboxyphosphonoenolpyruvate	Streptomyces hygroscopicus	first natural phosphinate	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	Streptomyces hygroscopicus	biosynthetic pathway that leads to the tripeptide antibiotic bialaphos, formation of one of the two C-P bonds in bialaphos	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	Streptomyces hygroscopicus SF1293	first natural phosphinate	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	Streptomyces hygroscopicus SF1293	biosynthetic pathway that leads to the tripeptide antibiotic bialaphos, formation of one of the two C-P bonds in bialaphos	(hydroxyphosphinyl)pyruvate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
no activity in Streptomyces hygroscopicus	-	-	-
Streptomyces hygroscopicus	-	HP782 and mutant NP71	-
Streptomyces hygroscopicus	-	SF1293	-
Streptomyces hygroscopicus SF1293	-	SF1293	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
carboxyphosphonoenolpyruvate	-	Streptomyces hygroscopicus	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	first natural phosphinate	Streptomyces hygroscopicus	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	biosynthetic pathway that leads to the tripeptide antibiotic bialaphos, formation of one of the two C-P bonds in bialaphos	Streptomyces hygroscopicus	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	-	Streptomyces hygroscopicus SF1293	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	first natural phosphinate	Streptomyces hygroscopicus SF1293	(hydroxyphosphinyl)pyruvate + CO2	-	?
carboxyphosphonoenolpyruvate	biosynthetic pathway that leads to the tripeptide antibiotic bialaphos, formation of one of the two C-P bonds in bialaphos	Streptomyces hygroscopicus SF1293	(hydroxyphosphinyl)pyruvate + CO2	-	?

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Release 2023.1 (January 2023)