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Literature summary for 2.7.8.2 extracted from
- 1-Alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (1992), Methods Enzymol., 209, 279-283.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | slight but significant stimulation | Gallus gallus |  |
| dithiothreitol | slight but significant stimulation | Homo sapiens | |
| dithiothreitol | slight but significant stimulation | Rattus norvegicus | |
| dithiothreitol | slight but significant stimulation | Oryctolagus cuniculus | |
| dithiothreitol | dithiothreitol-insensitive enzyme | Gallus gallus | |
| dithiothreitol | dithiothreitol-insensitive enzyme | Homo sapiens | |
| dithiothreitol | dithiothreitol-insensitive enzyme | Rattus norvegicus | |
| dithiothreitol | dithiothreitol-insensitive enzyme | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Oryctolagus cuniculus | |
| Ca2+ | above 0.01 mM | Rattus norvegicus | |
| ethanol | 2.5% | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Gallus gallus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | required | Rattus norvegicus | |
| Mg2+ | required | Oryctolagus cuniculus | |
| Mg2+ | maximal activation at 10-20 mM | Rattus norvegicus | |
| Mn2+ | - |
Homo sapiens | |
| Mn2+ | can partially replace Mg2+ in activation | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + sn-1,2-diacylglycerol | Gallus gallus | dithiothreitol-sensitive activity | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Homo sapiens | dithiothreitol-sensitive activity | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Rattus norvegicus | dithiothreitol-sensitive activity | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Oryctolagus cuniculus | dithiothreitol-sensitive activity | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Gallus gallus | final reaction in synthesis of phosphatidylcholine | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Homo sapiens | final reaction in synthesis of phosphatidylcholine | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Rattus norvegicus | final reaction in synthesis of phosphatidylcholine | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | Oryctolagus cuniculus | final reaction in synthesis of phosphatidylcholine | ? | - |
? | |
| additional information | Gallus gallus | dithiothreitol-insensitive activity | ? | - |
? | |
| additional information | Homo sapiens | dithiothreitol-insensitive activity | ? | - |
? | |
| additional information | Rattus norvegicus | dithiothreitol-insensitive activity | ? | - |
? | |
| additional information | Oryctolagus cuniculus | dithiothreitol-insensitive activity | ? | - |
? | |
| additional information | Gallus gallus | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | ? | - |
? | |
| additional information | Homo sapiens | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | ? | - |
? | |
| additional information | Rattus norvegicus | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | ? | - |
? | |
| additional information | Oryctolagus cuniculus | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Oryctolagus cuniculus | - |
| neutrophil | - |
Homo sapiens | - |
| retina | - |
Gallus gallus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacylglycerol | - |
Gallus gallus | CMP + a phosphatidylcholine | - |
? | |
| CDP-choline + 1,2-diacylglycerol | - |
Homo sapiens | CMP + a phosphatidylcholine | - |
? | |
| CDP-choline + 1,2-diacylglycerol | - |
Rattus norvegicus | CMP + a phosphatidylcholine | - |
? | |
| CDP-choline + 1,2-diacylglycerol | - |
Oryctolagus cuniculus | CMP + a phosphatidylcholine | - |
? | |
| CDP-choline + 1-hexadecyl-2-acetyl-sn-glycerol | - |
Rattus norvegicus | CMP + 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | dithiothreitol-sensitive activity | Gallus gallus | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | dithiothreitol-sensitive activity | Homo sapiens | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | dithiothreitol-sensitive activity | Rattus norvegicus | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | dithiothreitol-sensitive activity | Oryctolagus cuniculus | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | final reaction in synthesis of phosphatidylcholine | Gallus gallus | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | final reaction in synthesis of phosphatidylcholine | Homo sapiens | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | final reaction in synthesis of phosphatidylcholine | Rattus norvegicus | ? | - |
? | |
| CDP-choline + sn-1,2-diacylglycerol | final reaction in synthesis of phosphatidylcholine | Oryctolagus cuniculus | ? | - |
? | |
| additional information | - |
Gallus gallus | ? | - |
? | |
| additional information | higher activity with 16:0 and 18:1 substrates than with 18:0 substrates | Rattus norvegicus | ? | - |
? | |
| additional information | dithiothreitol-insensitive activity | Gallus gallus | ? | - |
? | |
| additional information | dithiothreitol-insensitive activity | Homo sapiens | ? | - |
? | |
| additional information | dithiothreitol-insensitive activity | Rattus norvegicus | ? | - |
? | |
| additional information | dithiothreitol-insensitive activity | Oryctolagus cuniculus | ? | - |
? | |
| additional information | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | Gallus gallus | ? | - |
? | |
| additional information | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | Homo sapiens | ? | - |
? | |
| additional information | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | Rattus norvegicus | ? | - |
? | |
| additional information | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | Oryctolagus cuniculus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
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