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Literature summary for 2.7.8.17 extracted from

  • Blanz, J.; Zunke, F.; Markmann, S.; Damme, M.; Braulke, T.; Saftig, P.; Schwake, M.
    Mannose 6-phosphate-independent lysosomal sorting of LIMP-2 (2015), Traffic, 16, 1127-1136.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information generation of GlcNAc-1-phosphotransferase-defective mice and enzyme-defective mouse embryonic fibroblasts Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Mus musculus 5794
-
Golgi apparatus
-
Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) is a mannose 6-phosphate-independent trafficking receptor for beta-glucocerebrosidase and no substrate of the enzyme, M6P-independent lysosomal sorting of LIMP-2, overview. beta-Glucocerebrosidase is also no substrate for the enzyme ?
-
?
UDP-N-acetyl-D-glucosamine + lysosomal-cathepsin Z D-mannose Homo sapiens
-
UMP + lysosomal-cathepsin Z N-acetyl-D-glucosaminyl-phospho-D-mannose
-
?
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose Mus musculus
-
UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose
-
?
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose Homo sapiens
-
UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q3T906 AND Q9UJJ9 alpha/beta-, and gamma-subunit encoding genes
-
Mus musculus Q69ZN6 AND Q6S5C2 alpha/beta-, and gamma-subunit encoding genes
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein an N-linked glycoprotein Mus musculus
glycoprotein an N-linked glycoprotein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
additional information no activity in fibroblasts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) is a mannose 6-phosphate-independent trafficking receptor for beta-glucocerebrosidase and no substrate of the enzyme, M6P-independent lysosomal sorting of LIMP-2, overview. beta-Glucocerebrosidase is also no substrate for the enzyme Homo sapiens ?
-
?
UDP-N-acetyl-D-glucosamine + lysosomal-cathepsin Z D-mannose
-
Homo sapiens UMP + lysosomal-cathepsin Z N-acetyl-D-glucosaminyl-phospho-D-mannose
-
?
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose
-
Mus musculus UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose
-
?
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose
-
Homo sapiens UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose
-
?

Synonyms

Synonyms Comment Organism
GlcNAc-1-phosphotransferase
-
Mus musculus
GlcNAc-1-phosphotransferase
-
Homo sapiens
GlcNAc-1PT
-
Mus musculus
GlcNAc-1PT
-
Homo sapiens
M6P-forming GlcNAc-1-phosphotransferase
-
Mus musculus
M6P-forming GlcNAc-1-phosphotransferase
-
Homo sapiens
M6P-forming N-acetylglucosamine-1-phosphotransferase
-
Mus musculus
M6P-forming N-acetylglucosamine-1-phosphotransferase
-
Homo sapiens

General Information

General Information Comment Organism
additional information the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) is a mannose 6-phosphate-independent trafficking receptor for beta-glucocerebrosidase and no substrate of the enzyme, M6P-independent lysosomal sorting of LIMP-2, overview Homo sapiens